Protective Effect of Human Endogenous Retrovirus K dUTPase Variants on Psoriasis Susceptibility  Olivia Y. Lai, Haoyan Chen, Henri-Alexandre Michaud, Genki Hayashi, Peter J. Kuebler, Gustaf K. Hultman, Maria-Eugenia Ariza, Marshall V. Williams, Mariana D. Batista, Douglas F. Nixon, John Foerster, Anne M. Bowcock, Wilson Liao  Journal of Investigative Dermatology  Volume 132, Issue 7, Pages 1833-1840 (July 2012) DOI: 10.1038/jid.2012.69 Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Location of human endogenous retrovirus K (HERV-K) sequence adjacent to HLA-C within the major histocompatibility complex region on chromosome 6. The PSORS1 susceptibility locus containing one or more psoriasis risk variants has been mapped in various studies to the region between HLA-B and HCG22. Cen: centromeric; Tel: telomeric. Scale at bottom is the human reference sequence assembly GRCh37/hg19. Journal of Investigative Dermatology 2012 132, 1833-1840DOI: (10.1038/jid.2012.69) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Linkage disequilibrium plot for HLA-C*06:02, HLA-B*57:01, and HERV-K dUTPase single-nucleotide polymorphisms (SNPs).r2 Values between pairs of SNPs are shown. Journal of Investigative Dermatology 2012 132, 1833-1840DOI: (10.1038/jid.2012.69) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 IgG antibody responses against recombinant human endogenous retrovirus K (HERV-K) dUTPase. The response against HERV-K dUTPase was screened using 23 psoriasis patient serum samples and 16 healthy donor serum samples at a 1:800 dilution. The human dUTPase was used as a control. Psoriasis subjects had a greater humoral response against HERV-K dUTPase compared with the healthy blood donors. No response against the human dUTPase was detected even at the lowest dilution used (data not shown). *P<0.05, Mann–Whitney U-test. Journal of Investigative Dermatology 2012 132, 1833-1840DOI: (10.1038/jid.2012.69) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions