mtDNA genotypes correlate with gut microbiota composition.

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Presentation transcript:

mtDNA genotypes correlate with gut microbiota composition. mtDNA genotypes correlate with gut microbiota composition. (A to E) 16S rRNA marker gene sequencing analysis of microbiota in fecal samples from C57BL/6J mice with the indicated mtDNA genotypes. Shannon diversity index (A) data and linear regression fit across groups of at least nine mice per group are from at least three independent breeding pairs per group. Principal coordinates analysis (PCoA) of (B) weighted UniFrac and (C) unweighted UniFrac distance between samples from all experiments. The percent total variation between samples is indicated on each axis, and ellipses represent the 80% confidence interval for samples in each group. The relative abundance of five major bacterial taxa (D) and Bacteroidetes/Firmicutes (B/F) ratio (E) with linear regression fit across all samples. *P < 0.05, **P < 0.01, and ***P < 0.001 by linear mixed-effects models with ordered factors (A), permutational multivariate analysis of variance (PERMANOVA) test (B and C), generalized linear mixed-effects models with ordered factors (D), or linear mixed-effects models on log-transformed ratios with ordered factors (E). Tal Yardeni et al., Sci. Signal. 2019;12:eaaw3159 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works