Unique Fc functional profiling of HIV-specific Abs from neutralizers.

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Sialylated IgG1 gp120-specific Abs are increased in neutralizers.

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Unique Fc functional profiling of HIV-specific Abs from neutralizers. Unique Fc functional profiling of HIV-specific Abs from neutralizers. (A to C) Serum Abs from neutralizers (N; purple) and non-neutralizers (NN; yellow) were evaluated for their ability to promote NK-dependent ADCC against gp120-pulsed CD4+ T cells (A), monocyte-directed phagocytosis of gp120-functionalized fluorescent beads (B), or complement deposition (C3b) on the surface of gp120-pulsed CD4+ target cells (C). All assays were performed in duplicate or triplicate across all 131 individuals. An unpaired t test was used for statistical analysis. *P < 0.05 and **P < 0.01. The horizontal bars in all panels indicate mean. Giuseppe Lofano et al. Sci. Immunol. 2018;3:eaat7796 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).