Rectal hyperreactivity to distention in patients with irritable bowel syndrome: role of distention rate Maura Corsetti, Bruno Cesana, Sherrie Bhoori,

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Rectal hyperreactivity to distention in patients with irritable bowel syndrome: role of distention rate Maura Corsetti, Bruno Cesana, Sherrie Bhoori, Guido Basilisco Clinical Gastroenterology and Hepatology Volume 2, Issue 1, Pages 49-56 (January 2004) DOI: 10.1016/S1542-3565(03)00291-X

Figure 1 Representative tracings showing results during slow (15 min) and fast distention (1.5 min) in (top) 1 healthy subject and (bottom) 1 patient with irritable bowel syndrome (IBS). The vertical axis shows intraballoon pressure (mm Hg), and the horizontal axis shows duration of distention (min). Markers indicate the occurrence of a sensation: first = sensation of gas, second = a desire to defecate. Black arrows indicate 2 rectal contractions. Note that intra-balloon pressure was greater during the fast than slow distention in both subjects and greater during fast distention in the patient than the healthy subject. The patient experienced more sensations during both the slow and fast distention; during fast distention, there were 2 rectal contractions followed by a sensation. Clinical Gastroenterology and Hepatology 2004 2, 49-56DOI: (10.1016/S1542-3565(03)00291-X)

Figure 2 Pressure-volume relationships during slow (square symbols) and fast distentions (triangular symbols) in healthy subjects (unfilled symbols) and patients with IBS (filled symbols). Values shown as mean ± SD. The slope of the pressure-volume relationship was significantly higher during fast than slow distention in both groups (P = 0.021 in healthy subjects; P < 0.0001 in patients with IBS) and significantly higher in patients with IBS during fast distention (P = 0.0006), but not during slow distention (P = 0.07). Clinical Gastroenterology and Hepatology 2004 2, 49-56DOI: (10.1016/S1542-3565(03)00291-X)

Figure 3 Frequency of the number of rectal contractions per minute by distention rate in healthy subjects (HS; white column) and patients with irritable bowel syndrome (IBS; black column). Values shown as mean ± SD. ∗P < 0.025 vs. slow distention. $P < 0.025 vs. healthy subjects. Clinical Gastroenterology and Hepatology 2004 2, 49-56DOI: (10.1016/S1542-3565(03)00291-X)

Figure 4 Frequency of the number of sensations per minute by distention rate in healthy subjects (HS) and patients with irritable bowel syndrome (IBS), including proportions of the sensations of gas, a desire to defecate, and urgency. Values shown as mean ± SD. ∗P < 0.001 vs. slow distention. $P < 0.025 vs. healthy subjects. Clinical Gastroenterology and Hepatology 2004 2, 49-56DOI: (10.1016/S1542-3565(03)00291-X)