Statistical Mechanics of Pluripotency

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Statistical Mechanics of Pluripotency Ben D. MacArthur, Ihor R. Lemischka Cell Volume 154, Issue 3, Pages 484-489 (August 2013) DOI: 10.1016/j.cell.2013.07.024 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Entropy and Developmental Potency The permissive regulatory architecture of PSCs imposes weak constraints on mRNA/protein expression, giving rise to high-entropy expression patterns within the population. As differentiation progresses expression patterns become more tightly constrained and population entropy decreases. Cell 2013 154, 484-489DOI: (10.1016/j.cell.2013.07.024) Copyright © 2013 Elsevier Inc. Terms and Conditions