Delayed eosinophil apoptosis in asthma

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Presentation transcript:

Delayed eosinophil apoptosis in asthma Hannu Kankaanranta, MD, PhDb,c, Mark A. Lindsay, PhDa, Mark A. Giembycz, PhDa, Xianzhi Zhang, MScb, Eeva Moilanen, MD, PhDb,d, Peter J. Barnes, MD, DM, DSc, FRCPa Journal of Allergy and Clinical Immunology Volume 106, Issue 1, Pages 77-83 (July 2000) DOI: 10.1067/mai.2000.107038 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Apoptosis index after 48 hours of culture in eosinophils from healthy subjects and patients with asthma either using or not using corticosteroids. Error bars indicate mean ± SEM. ns, Not significant. Journal of Allergy and Clinical Immunology 2000 106, 77-83DOI: (10.1067/mai.2000.107038) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 The effects of neutralization of IL-3, IL-5, and GM-CSF on eosinophil apoptosis index. Eosinophils from patients with asthma not using inhaled steroids were cultured with IgG1 isotype control (5 μg/mL) or with neutralizing mAbs to IL-3, IL-5, or GM-CSF (5 μg/mL) for 48 hours. When all neutralizing antibodies (at 5 μg/mL each) were added to the same culture, the isotype control IgG1 was used at 15 μg/mL. Each data point represents eosinophils from a single donor. For details see Methods. Journal of Allergy and Clinical Immunology 2000 106, 77-83DOI: (10.1067/mai.2000.107038) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 The inhibitory effect (percentage inhibition) of albuterol, fenoterol, and salmeterol on apoptosis during 48 hours of culture in eosinophils isolated from the blood of healthy volunteers. Mean ± SEM, n = 5. Asterisk, P < .05; two asterisks, P < .01 compared with the respective solvent control. Journal of Allergy and Clinical Immunology 2000 106, 77-83DOI: (10.1067/mai.2000.107038) Copyright © 2000 Mosby, Inc. Terms and Conditions