Signal transducer and activator of transcription 5 tyrosine phosphorylation for the diagnosis and monitoring of patients with severe combined immunodeficiency

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

What drives prescription patterns in pediatric asthma management?

The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency Rita Carsetti, MD, Maria Manuela Rosado, PhD, Simona.

Expression of IL-9 receptor α chain on human germinal center B cells modulates IgE secretion Lama M. Fawaz, PhD, Ehssan Sharif-Askari, PhD, Oumnia Hajoui,

Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency Chiara Bacchelli, PhD, Federico A. Moretti,

Combined immunodeficiency due to JAK3 mutation in a child presenting with skin granuloma Alessia Scarselli, MD, Silvia Di Cesare, BSc, Gigliola Di Matteo,

Fatty acids, inflammation, and asthma

Laurent L'homme, PhD, David Dombrowicz, PhD

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency Chiara Bacchelli, PhD, Federico A. Moretti,

Diagnosing IgE-mediated hypersensitivity to sesame by an immediate-reading “contact test” with sesame oil Cristiana Alonzi, MD, Paolo Campi, MD, Francesco.

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Intramuscular Versus Intravenous Immunoglobulin Replacement Therapy and Measurement of Immunoglobulin Levels During Immunoglobulin Replacement Therapy

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Fatty acids, inflammation, and asthma

Long-term immune reconstitution and clinical outcome after stem cell transplantation for severe T-cell immunodeficiency Evelina Mazzolari, MD, Concetta.

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Peter M. Wolfgram, MD, David B. Allen, MD

Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription.

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Reply Journal of Allergy and Clinical Immunology

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Food allergy in patients with primary immunodeficiency diseases: Prevalence within the US Immunodeficiency Network (USIDNET) Karen S. Tuano, MD, Jordan.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Expression of IL-9 receptor α chain on human germinal center B cells modulates IgE secretion Lama M. Fawaz, PhD, Ehssan Sharif-Askari, PhD, Oumnia Hajoui,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Common variable immunodeficiency and natural killer cell lymphopenia caused by Ets- binding site mutation in the IL-2 receptor γ (IL2RG) gene promoter

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

What is an “eosinophilic phenotype” of asthma?

Weiguo Chen, PhD, Gurjit K. Khurana Hershey, MD, PhD

Cephalosporin Side Chain Cross-reactivity

Mechanism-Based Precision Therapy for the Treatment of Primary Immunodeficiency and Primary Immunodysregulatory Diseases Jennifer W. Leiding, MD, Lisa.

Medication use in children with asthma in Finland from 1995 to 2006

Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites Zhikang Peng, MD, Andrew N. Beckett, BSc,

Granulomatous-lymphocytic Interstitial Lung Disease in a Patient with Common Variable Immunodeficiency Phil Lieberman, MD, John Routes, MD The Journal.

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Personalized asthma therapy in blacks—the role of genetic ancestry

Autophagy: Nobel Prize 2016 and allergy and asthma research

IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets Sven Létourneau, DPhil, Carsten Krieg, PhD, Giuseppe Pantaleo,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

Persistence of natural killer cells with expansion of a hypofunctional CD56−CD16+KIR+NKG2C+ subset in a patient with atypical Janus kinase 3–deficient.

Bruce G. Bender, PhD, Alex Pedan, PhD, Laleh T. Varasteh, RPh, MSF

Risk of oral food challenges

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

Self-administration of C1-inhibitor concentrate in patients with hereditary or acquired angioedema caused by C1-inhibitor deficiency Marcel Levi, MD,

Xiu-Min Li, MD, LaVerne Brown, PhD

TH9 immunodeficiency in patients with hyper-IgE syndrome

Anaphylaxis Journal of Allergy and Clinical Immunology

Measles and immunomodulation

Päivi M. Salo, PhD, Samuel J. Arbes, DDS, MPH, PhD, Patrick W

Macrolide antibiotics and asthma treatment

Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.

Asthma: The past, future, environment, and costs

Interrupting IL-6–receptor signaling improves atopic dermatitis but associates with bacterial superinfection Alexander A. Navarini, MD, PhD, Lars E.

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Janet Chou, MD, Maxim Lutskiy, MD, PhD, Erdyni Tsitsikov, PhD, Luigi D

Environmental factors and eosinophilic esophagitis

Kinase inhibitors in clinical practice: An expanding world

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Advances in pediatric asthma in 2007

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Presentation transcript:

Signal transducer and activator of transcription 5 tyrosine phosphorylation for the diagnosis and monitoring of patients with severe combined immunodeficiency Denise Walshe, FIBMS, CSci, H. Bobby Gaspar, MD, PhD, Adrian J. Thrasher, MD, PhD, Catherine M. Cale, MD, PhD, Kimberly C. Gilmour, PhD Journal of Allergy and Clinical Immunology Volume 123, Issue 2, Pages 505-508 (February 2009) DOI: 10.1016/j.jaci.2008.11.041 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Tyrosine-phosphorylated STAT5 is detected in a control subject but not in a γc-deficient patient. A, γc Staining. B, EMSA showing cells stimulated with IL-2. C, STAT5 ptyr staining on unstimulated (black) and IL-2–stimulated (gray) cells. C, Control; P, patient with γc SCID (patient 1); Co/Po, control/patient plus specific oligonucleotide; PMF, patient with maternal fetal engraftment (patient 14). D, Graph showing the mean and SD percentage change in STAT5 ptyr in control subjects and subjects with combined immunodeficiencies/SCIDs, γc/JAK3 SCIDs (samples with maternal-fetal engraftment not included), and γc SCIDs after therapy. Journal of Allergy and Clinical Immunology 2009 123, 505-508DOI: (10.1016/j.jaci.2008.11.041) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions