Volume 65, Issue 6, Pages (June 2004)

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Volume 65, Issue 6, Pages 2193-2200 (June 2004) Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy Ariela Benigni, Elena Gagliardini, Susanna Tomasoni, Mauro Abbate, Piero Ruggenenti, Raghu Kalluri, Giuseppe Remuzzi Kidney International Volume 65, Issue 6, Pages 2193-2200 (June 2004) DOI: 10.1111/j.1523-1755.2004.00636.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Representative pictures of nephrin mRNA expression by in situ hybridization in patients with diabetes (A) or minimal change nephrosis (B), and in control kidney (C and E). No specific signal was obtained with the sense nephrin probe (control kidney) (D). Arrows indicate podocyte nephrin expression. Original magnification, ×250 (A-D), and ×1000 (E). Kidney International 2004 65, 2193-2200DOI: (10.1111/j.1523-1755.2004.00636.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Representative photomicrographs of nephrin extracellular domain by the immunoperoxidase method in patients with diabetes (A) or minimal change nephrosis (B), and in control kidney (C). No specific signal was obtained omitting the primary antibody (D). Original magnification, ×250. Kidney International 2004 65, 2193-2200DOI: (10.1111/j.1523-1755.2004.00636.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 Representative photomicrographs of nephrin intracellular domain by the immunoperoxidase method in patients with diabetes (A) or minimal change nephrosis (B), and in control kidney (C). No specific signal was obtained omitting the primary antibody (D). Original magnification, ×250. Kidney International 2004 65, 2193-2200DOI: (10.1111/j.1523-1755.2004.00636.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 4 Immunoperoxidase staining for CD2AP and podocin in patients with diabetes (A and E) or minimal change nephrosis (B and F), and in control kidney (C and G). No signal was obtained omitting the primary antibody (D and H). Original magnification, ×250. Kidney International 2004 65, 2193-2200DOI: (10.1111/j.1523-1755.2004.00636.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 5 Representative transmission electron micrographs of the ultrastructure capillary wall in patients with diabetes (A) and in control kidneys (B). (C) An enlarged detail of (B) representing the distance between two adjacent foot processes used to quantify the slit diaphragm width is shown. Arrows indicate electron dense diaphragms in the filtration slits. Original magnification, ×36,000. Kidney International 2004 65, 2193-2200DOI: (10.1111/j.1523-1755.2004.00636.x) Copyright © 2004 International Society of Nephrology Terms and Conditions