Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study.

Slides:

Advertisements

Similar presentations

Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women Featured Article: Peter Würtz, Ph.D., Mika Tiainen, M.S.C., Ville-Petteri Mäkinen,

Advertisements

Glucose Levels and Risk of Dementia Presented by - Anas Kabaha, MD Sheba medical center Sheba medical center August 8,2013.

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.

Date of download: 6/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Major Lipids, Apolipoproteins, and Risk of Vascular.

Effect of fatty and lean fish intake on lipoprotein subclasses in subjects with coronary heart disease: A controlled trial Arja T. Erkkilä, PhD, Ursula.

Volume 1, Issue 4, Pages (October 2015)

CHA2DS2-VASC and CHADS2 Scores Predict Adverse Clinical Events in Patients With Pacemakers and Sinus Node Dysfunction Independent of Atrial Fibrillation

Microvascular disease and risk of cardiovascular events among individuals with type 2 diabetes: a population-level cohort study Dr Jack R W Brownrigg,

Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: The Cardiovascular Risk in Young Finns Study David P. Burgner,

Volume 386, Issue 9989, Pages (July 2015)

Copyright © 2014 American Medical Association. All rights reserved.

Volume 376, Issue 9750, Pages (October 2010)

Comprehensive lipid and metabolite profiling of children with and without familial hypercholesterolemia: A cross-sectional study Jacob J. Christensen,

Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: The Cardiovascular Risk in Young Finns Study David P. Burgner,

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies The Emerging.

Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow- mediated dilation and carotid artery distensibility: The Cardiovascular.

Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people Dr Anoop Dinesh Shah, MRCP, Claudia Langenberg, PhD, Eleni.

Low-Density Lipoprotein Cholesterol, Non–High-Density Lipoprotein Cholesterol, Triglycerides, and Apolipoprotein B and Cardiovascular Risk in Patients.

Individual omega-9 monounsaturated fatty acids and mortality—The Ludwigshafen Risk and Cardiovascular Health Study Graciela E. Delgado, MSc, Bernhard.

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Olli T. Raitakari, Ville-Petteri Mäkinen, Matthew J

Copyright © 2012 American Medical Association. All rights reserved.

Sunjoo Boo, RN, PhD, Erika Sivarajan Froelicher, RN, PhD, FAAN

Prehypertension, Diabetes, and Cardiovascular Disease Risk in a Population-Based Sample by Ying Zhang, Elisa T. Lee, Richard B. Devereux, Jeunliang Yeh,

Hazard ratio (HR) for mortality for a 1-kg/m2 increase in body mass index (BMI) across the range of baseline BMI among patients with acute ischemic stroke.

Masaya Koshizaka, MD, PhD, Renato D. Lopes, MD, PhD, MHS, L

Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: The Framingham Heart.

The prevalence of abdominal aortic aneurysm is consistently high among patients with coronary artery disease Jussi A. Hernesniemi, MD, PhD, Ville Vänni,

Shoshana H. Ballew, PhD, Yan Chen, BS, Natalie R. Daya, MPH, Job G

Volume 375, Issue 9709, Pages (January 2010)

Volume 376, Issue 9750, Pages (October 2010)

Apolipoprotein E-containing high-density lipoprotein (HDL) modifies the impact of cholesterol-overloaded HDL on incident coronary heart disease risk:

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies The Emerging.

An update on cardiovascular disease epidemiology in South East Asia

Volume 1, Issue 4, Pages (October 2015)

Effect of fatty and lean fish intake on lipoprotein subclasses in subjects with coronary heart disease: A controlled trial Arja T. Erkkilä, PhD, Ursula.

Blood Lead Levels and Decreased Kidney Function in a Population-Based Cohort Florencia Harari, Gerd Sallsten, Anders Christensson, Marinka Petkovic, Bo.

Cardiovascular Disease and CKD: Core Curriculum 2010

Dileep Raman et al. JACEP 2017;3:

Long-term Adherence to Healthy Dietary Guidelines and Chronic Inflammation in the Prospective Whitehall II Study Tasnime N. Akbaraly, PhD, Martin J.

Sunjoo Boo, RN, PhD, Erika Sivarajan Froelicher, RN, PhD, FAAN

Self-Management of Anticoagulant Therapy in Mechanical Heart Valve Patients: A Matched Cohort Study Thomas Decker Christensen, MD, PhD, Flemming Skjøth,

Blood Lead Levels and Decreased Kidney Function in a Population-Based Cohort Florencia Harari, Gerd Sallsten, Anders Christensson, Marinka Petkovic, Bo.

Description of studies for pooled analyses

Mika Kivimäki, Ritva Luukkonen, G. David Batty, Jane E

The prevalence of abdominal aortic aneurysm is consistently high among patients with coronary artery disease Jussi A. Hernesniemi, MD, PhD, Ville Vänni,

Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies

Wesley T. O’Neal et al. JACEP 2016;2:

Higher systolic blood pressure is associated with progression of carotid intima–media thickness in patients with chronic kidney disease Jessica Kendrick,

Volume 379, Issue 9822, Pages (March 2012)

Molly E. Waring, PhD, Jane S

Volume 79, Issue 12, Pages (June 2011)

Vitality Measured as Self-reported Energy Level and Clinical Outcomes in Hemodialysis Patients: The Japanese Dialysis Outcomes and Practice Pattern Study.

Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study Kumar B. Rajan, Jennifer Weuve,

Volume 376, Issue 9750, Pages (October 2010)

Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people Dr Anoop Dinesh Shah, MRCP, Claudia Langenberg, PhD, Eleni.

Volume 379, Issue 9822, Pages (March 2012)

Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study Kumar B. Rajan, Jennifer Weuve,

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies The Emerging.

Anne L. M. Vlek, MD, Yolanda van der Graaf, MD, PhD, Maayke A

Volume 383, Issue 9921, Pages (March 2014)

Performance of Framingham cardiovascular disease (CVD) predictions in the Rotterdam Study taking into account competing risks and disentangling CVD into.

International Journal of Cardiology

Lars E. Laugsand et al. BTS 2016;j.jacbts

Sven J. van der Lee, Charlotte E. Teunissen, René Pool, Martin J

Diabetes, prediabetes, and cardiovascular risk: Shifting the paradigm

Volume 75, Issue 1, Pages (January 2009)

Shoshana H. Ballew, PhD, Yan Chen, BS, Natalie R. Daya, MPH, Job G

Increased risk for dementia both before and after stroke: A population-based study in women followed over 44 years Xinxin Guo, Svante Östling, Silke.

Hazard ratios, with 95% confidence intervals as floating absolute risks, as estimate of association between category of updated mean haemoglobin A1c concentration.

Presentation transcript:

Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts Juho Tynkkynen, Vincent Chouraki, Sven J. van der Lee, Jussi Hernesniemi, Qiong Yang, Shuo Li, Alexa Beiser, Martin G. Larson, Katri Sääksjärvi, Martin J. Shipley, Archana Singh-Manoux, Robert E. Gerszten, Thomas J. Wang, Aki S. Havulinna, Peter Würtz, Krista Fischer, Ayse Demirkan, M. Arfan Ikram, Najaf Amin, Terho Lehtimäki, Mika Kähönen, Markus Perola, Andres Metspalu, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Ramachandran S. Vasan, Mika Kivimäki, Cornelia M. van Duijn, Sudha Seshadri, Veikko Salomaa Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 14, Issue 6, Pages 723-733 (June 2018) DOI: 10.1016/j.jalz.2018.01.003 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 A forest plot describing the meta-analysis results of all eight cohorts combined (n = 22,623/995, participants/incident dementia cases). Results are adjusted for model 2. Model 2 includes age, sex, education grade, number of APOE ε4 alleles, systolic blood pressure, hypertension treatment, prevalent diabetes, current smoking, and any prevalent cardiovascular disease (atrial fibrillation, coronary heart disease, heart failure, stroke, or peripheral artery disease) as covariates. HRs and 95% CIs are shown per one SD of rank inverse normal transformed metabolite concentration. Abbreviations: APOE, apolipoprotein E; CIs, confidence intervals; HRs, hazard ratios; SD, standard deviation; AD, Alzheimer's disease; CREA, creatinine; SFA-FA, Ratio of saturated fatty acids to total fatty acids; ILE, isoleucine; LEU, leucine; VAL, valine; L-HDL-CE-%, Cholesterol esters to total lipids ratio in large HDL; L-HDL-PL-%, phospholipids to total lipids ratio in large HDL; S-VLDL-C, Total cholesterol in small VLDL; XL-VLDL-C-%, Total cholesterol to total lipids ratio in very large VLDL; XL-VLDL-TG-%, Triglycerides to total lipids ratio in very large VLDL. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2018 14, 723-733DOI: (10.1016/j.jalz.2018.01.003) Copyright © 2018 The Authors Terms and Conditions