The effects of IL-5 on airway physiology and inflammation in rats

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Presentation transcript:

The effects of IL-5 on airway physiology and inflammation in rats Sammy S. Nag, MSca, Li Jing Xu, MSCb, Qutayba Hamid, MDb, Paolo M. Renzi, MDa Journal of Allergy and Clinical Immunology Volume 111, Issue 3, Pages 558-566 (March 2003) DOI: 10.1067/mai.2003.131 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Effect of rhIL-5 on eosinophil (eos )/basophil (baso ) type colony production in rat PBMNCs (n = 10). *P < .05 between IL-5 groups (1, 2, and 5 ng/mL) and control. Journal of Allergy and Clinical Immunology 2003 111, 558-566DOI: (10.1067/mai.2003.131) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 A, Effect of IL-5 on airway responsiveness to methacholine (Mch) 20 hours after administration. EC200RL was calculated as the amount of Mch necessary to double RL. Bars represent the means of each group. EU , Endotoxin units; LPS , lipopolysaccharide. *P < .05 between IL-5 treated (3 μg) and BSA treated (control). **P < .01 between IL-5 treated (10 μg) and BSA treated (control). ***P < .05 between IL-5 treated (10 μg) and 10 μg IL-5 with 50 ng TRFK5. B, Effect of 10 μg of IL-5 on airway responsiveness to Mch 30 minutes and 72 hours after administration (n = 22). Bars represent the arithmetic means of each group. Journal of Allergy and Clinical Immunology 2003 111, 558-566DOI: (10.1067/mai.2003.131) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 Effect of rhIL-5 on RL 20 hours after antigen challenge. Rats (n = 12) were given 3 μg of rhIL-5 or BSA and challenged with ovalbumin 20 hours later. RL was measured 20 hours after antigen challenge in both groups of rats. Bars represent the mean of each group. *P < .05 between IL-5 treated/challenged and control groups. Journal of Allergy and Clinical Immunology 2003 111, 558-566DOI: (10.1067/mai.2003.131) Copyright © 2003 Mosby, Inc. Terms and Conditions