Protective effect of glycine in mesenteric ischemia and reperfusion injury in a rat model Sreedhar Kallakuri, MD, Enrico Ascher, MD, Murali Pagala, PhD,

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Protective effect of glycine in mesenteric ischemia and reperfusion injury in a rat model Sreedhar Kallakuri, MD, Enrico Ascher, MD, Murali Pagala, PhD, Prasad Gade, MD, Anil Hingorani, MD, Marcel Scheinman, MD, Khodadad Mehraein, MD, Theresa Jacob, PhD Journal of Vascular Surgery Volume 38, Issue 5, Pages 1113-1120 (November 2003) DOI: 10.1016/S0741-5214(03)00939-X

Fig 1 Morphometric analysis of ileal ischemia-reperfusion injury with SigmaScan (×100). A, Total thickness of bowel wall; B, mucosal thickness; C, thickness of muscularis; D, total villar circumference; E, length at base of villi. Villous circumference ratio calculated as D/E. Total villar circumference covered by epithelium (T = F to I) and circumference of villar regions not covered by epithelium (N = H1 to H2) were measured for entire quadrant, and percentage of epithelial coverage was calculated as ([T − N]/T) × 100. Journal of Vascular Surgery 2003 38, 1113-1120DOI: (10.1016/S0741-5214(03)00939-X)

Fig 2 Normal nonischemic ileum (×100). Journal of Vascular Surgery 2003 38, 1113-1120DOI: (10.1016/S0741-5214(03)00939-X)

Fig 3 Ileum after 1 hour of ischemia and 2 hours of reperfusion in saline solution–treated control rats (×100). Journal of Vascular Surgery 2003 38, 1113-1120DOI: (10.1016/S0741-5214(03)00939-X)

Fig 4 Ileum after 1 hour of ischemia and 2 hours of reperfusion in glycine-treated rats (×100). Journal of Vascular Surgery 2003 38, 1113-1120DOI: (10.1016/S0741-5214(03)00939-X)

Fig 5 Peak contractile tension responses evoked with electrical stimulation at 30 Hz, 120 mmol/L of potassium, and 5 μmol/L of carbachol in proximal segment of small bowel in normal, saline solution–treated, and glycine (0.5 mg/g/h)–treated rats. Bars represent mean value; vertical lines represent standard error, obtained from number of rats given in parentheses. *Significance of difference between value of each parameter in saline solution–treated and glycine-treated segments, evaluated with the Student t test. Journal of Vascular Surgery 2003 38, 1113-1120DOI: (10.1016/S0741-5214(03)00939-X)

Fig 6 Peak contractile tension responses in middle segment of small bowel in normal, saline solution–treated, and glycine (0.5 mg/g/h)–treated rats. Bars represent mean value; vertical lines represent standard error, obtained from number of rats given in parentheses. *Significance of difference between value of each parameter in saline solution–treated and glycine-treated segments, evaluated with the Student t test. Journal of Vascular Surgery 2003 38, 1113-1120DOI: (10.1016/S0741-5214(03)00939-X)

Fig 7 Peak contractile tension responses in middle segment of small bowel in normal, saline solution–treated, and glycine (0.5 mg/g/h)–treated small bowel of the rats. Bars represent mean value; vertical lines represent standard error, obtained from number of rats given in parentheses. *Significance of difference between value of each parameter in saline solution–treated and glycine-treated segments, evaluated with the Student t test. Journal of Vascular Surgery 2003 38, 1113-1120DOI: (10.1016/S0741-5214(03)00939-X)