A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery.

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Presentation transcript:

A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial) Paula M. Bokesch, MD, Gabor Szabo, MD, Ryszard Wojdyga, MD, Hilary P. Grocott, MD, FRCPC, Peter K. Smith, MD, C. David Mazer, MD, FRCPC, Santosh Vetticaden, MD, PhD, Alistair Wheeler, MD, Jerrold H. Levy, MD, FAHA The Journal of Thoracic and Cardiovascular Surgery Volume 143, Issue 5, Pages 1022-1029 (May 2012) DOI: 10.1016/j.jtcvs.2011.06.001 Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 CONSORT flow diagram. The Journal of Thoracic and Cardiovascular Surgery 2012 143, 1022-1029DOI: (10.1016/j.jtcvs.2011.06.001) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Mean cumulative volume of PRBCs transfused during surgery through hospital discharge. ∗∗∗P < .001 for comparison between treatment groups (Wilcoxon rank-sum test). CI, Confidence interval; PRBC, packed red blood cell. The Journal of Thoracic and Cardiovascular Surgery 2012 143, 1022-1029DOI: (10.1016/j.jtcvs.2011.06.001) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 The effect of tranexamic dose on transfusion of PRBC. P values based on the Wilcoxon rank-sum test. CI, Confidence interval; PRBC, packed red blood cell. The Journal of Thoracic and Cardiovascular Surgery 2012 143, 1022-1029DOI: (10.1016/j.jtcvs.2011.06.001) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions