A) Molecular structure and b) schematic diagram of immunoglobulin (Ig)E. a) Molecular structure and b) schematic diagram of immunoglobulin (Ig)E. The variable.

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a) Molecular structure and b) schematic diagram of immunoglobulin (Ig)E. a) Molecular structure and b) schematic diagram of immunoglobulin (Ig)E. The variable domain (V) binds antigen. The constant region (C) domains determine secondary biological function (e.g. cell-surface binding). FcϵRI and FcϵRII are high-affinity IgE receptors. Fab: antigen-binding fragment; Fc: crystallisable fragment; VH: heavy-chain variable domain; VL: light-chain variable domain; CH: heavy-chain constant domain; CL: light-chain variable domain. E. Hamelmann Eur Respir Rev 2007;16:61-66 ©2007 by European Respiratory Society