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Volume 73, Issue 5, Pages 651-655 (March 2008) HIV-related nephropathies associated with changes in blood and kidney tissue virus load V. Audard, J. Avouac, M. Wirden, A. Pardon, M. Matignon, P. Remy, D. Desvaux, P. Lang, P. Grimbert Kidney International Volume 73, Issue 5, Pages 651-655 (March 2008) DOI: 10.1038/sj.ki.5002765 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 First renal biopsy. (a) Light microscopy of the first renal biopsy (June 2004) showing focal lupus-like glomerulonephritis. The glomerulus appeared with mesangial and endocapillary hypercellularity (arrow). Tubules are not dilated and a mild interstitial infiltrate is present (Masson's trichrome stains, original magnification × 400). Immunofluorescence study revealed an intense granular glomerular staining in capillary walls and mesangium on the first renal biopsy using C1q (b) and IgM (c) antibodies. Kidney International 2008 73, 651-655DOI: (10.1038/sj.ki.5002765) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 Light microscopy study on the second renal biopsy (November 2004) showed typical findings of HIVAN with collapse of the glomerular tuft and tubular dilatation. Visceral epithelial cells form a cellular corona over the lobules (arrow). Reactive blood mononuclear cells were found in the interstitium (Masson's trichrome stains, original magnification × 400). Kidney International 2008 73, 651-655DOI: (10.1038/sj.ki.5002765) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 3 Light microscopy of the third renal biopsy (September 2005) revealed diffuse proliferative lupus-like glomerulonephritis with segmental cellular crescents observed in more than 50% of glomeruli (arrow). Mild interstitial infiltrate was associated with glomerular lesions. (Masson's trichrome stains, original magnification × 400). Kidney International 2008 73, 651-655DOI: (10.1038/sj.ki.5002765) Copyright © 2008 International Society of Nephrology Terms and Conditions