De novo prions are infectious.

Slides:

Advertisements

Similar presentations

Distribution of Zn isotopes during Alzheimer’s disease

Advertisements

C. albicans murine gastrointestinal colonization is lower in mice fed a diet containing coconut oil than in mice fed a diet containing beef tallow or soybean.

In vitro and in vivo replication of MKWV and interferon-antagonism activity of MKWV NSs. (a) MKWV isolate MKW73 was used to inoculate cells derived from.

Acid stability of the HA protein of clade

Localization of Gammaproteobacteria and evidence of Proteobacteria migration into the crypts within the distal colon of mice inoculated with C. rodentium.

Treatment of SFTSV-infected IFNAR−/− mice with T-705 or ribavirin.

Fatty acid composition of beef tallow, soybean oil, and coconut oil and weight of mice fed diets containing those fats. Fatty acid composition of beef.

Disruption of the BGLF2 gene decreased infectious progeny production.

MFS1 expression in parental and progeny strains.

DNSP16 mutation attenuates the virulence of a mouse-adapted MERS-CoV strain. dNSP16 mutation attenuates the virulence of a mouse-adapted MERS-CoV strain.

Antimicrobial zone of inhibition.

De novo generation of infectious ZIKVNatal by CPER

Nonhematopoietic cells help regulate the pathogenic adaptive immune response during the second peak of joint swelling. Nonhematopoietic cells help regulate.

CD4 T cells are responsible for the intensified joint pathology at 6 d postinfection. CD4 T cells are responsible for the intensified joint pathology at.

Histological changes in mouse colons after DSS treatment.

FepB is responsible for the smr mutant’s phenotype.

The pho4Δ mutant is less virulent than the WT strain in intranasal (A to C) and intravenous (D to F) models of cryptococcosis. The pho4Δ mutant is less.

Inhibitory effect of T-705, ribavirin, T-1105, and T-1106 on SFTSV replication in Vero cells. Inhibitory effect of T-705, ribavirin, T-1105, and T-1106.

Comparative analysis of Aeromonas sp.

FLC treatment results in an increase in ploidy in a significant fraction of cells. FLC treatment results in an increase in ploidy in a significant fraction.

Changing to a coconut oil-containing diet reduces preexisting GI colonization by C. albicans. Changing to a coconut oil-containing diet reduces preexisting.

The distribution of Sias in tissues from 10-day postfertilization embryonated chicken eggs. The distribution of Sias in tissues from 10-day postfertilization.

Protein sequence alignments for the BcfD (A) and StfH (B) allelic groups from S. Newport. Protein sequence alignments for the BcfD (A) and StfH (B) allelic.

Transcriptomic analysis of Jamaican fruit bats infected with Tacaribe virus (TCRV). Transcriptomic analysis of Jamaican fruit bats infected with Tacaribe.

Urine ammonia is highly correlated with plasma K

Side-view and apical-view projections of mutant and validation strain biofilms. Side-view and apical-view projections of mutant and validation strain biofilms.

Relative ITS2 abundance of Saccharomyces in stool over time as a Saccharomyces cerevisiae-free diet was consumed. Relative ITS2 abundance of Saccharomyces.

Relative growth of WT R2866 and the R2866ΔampG gene deletion mutant with Triton X-100. Relative growth of WT R2866 and the R2866ΔampG gene deletion mutant.

FMDV infection dynamics in cattle in phase II of the study.

Stress-protective roles of C. auris Hog1.

Activity of TP-271 administered i. v. and p. o

Numbers of L. plantarum AJ11 and L

Dynamic ranges of anti-PnPS IgG Reference standard serum 007sp for each of 13 serotypes. Dynamic ranges of anti-PnPS IgG Reference standard serum 007sp.

Unchanged worm burden and microfilaremia in basophil-deficient mice compared with their basophil-competent littermates. Unchanged worm burden and microfilaremia.

Shifts in the microbial community compositions of the control and antibiotic groups. Shifts in the microbial community compositions of the control and.

BTG2 regulates gluconeogenic gene expression in diabetic mouse models

De novo prions display and propagate distinct conformational stabilities. De novo prions display and propagate distinct conformational stabilities. We.

Planarian brain regeneration.

De novo generation of cervid prions.

Normalized weight gain of protein-sufficient and -deficient pigs after HRV inoculation and HIFM transplantation monitored over a period of 4 weeks. Normalized.

OVA-specific and InvaplexNAT-specific serum IgG endpoint titers in mice after intranasal immunization with OVA alone or OVA combined with InvaplexAR, InvaplexNAT,

Prime and boosts with PBK001 vaccine provided 100% protection with low bacterial burden in organs. Prime and boosts with PBK001 vaccine provided 100% protection.

Therapeutic effect of IL-12/ms treatment on gonococcal infection depends on both IFN-γ and B cells. Therapeutic effect of IL-12/ms treatment on gonococcal.

d-Serine utilization contributes to fitness of P

Bacterial composition of olive fermentations is affected by microbial inoculation. Bacterial composition of olive fermentations is affected by microbial.

Heterotrophic and autotrophic particle (cell) abundance in water column. Heterotrophic and autotrophic particle (cell) abundance in water column. Small.

Stress resistance comparisons.

KEGG cluster of DEGs of S

Sequence comparisons of fungal HOG1 orthologues.

OMV-enriched proteins show a conserved N-terminal LES motif.

Intranasal immunization of mice with S

CT production profiles of single-SNP strains and double-, triple-, and quadruple-SNP combination strains. CT production profiles of single-SNP strains.

Procrustes analysis comparing the spatial fit of unweighted UniFrac principal-coordinate matrices of bacterial communities (yellow spheres) and Bray-Curtis.

mTORC1 is required for malignant transformation in the Eμ-Myc model.

OMVs displaying WT SusG can rescue a strain with a ΔsusG growth phenotype on starch as the carbon source. OMVs displaying WT SusG can rescue a strain with.

Taxonomical distribution of the major phyla in the inoculum and gnotobiotic chicken gut at day 9 and day 18. Taxonomical distribution of the major phyla.

B. fragilis utilizes TLR2 signaling for its protective role against the development of colitis-associated cancer in mice. B. fragilis utilizes TLR2 signaling.

Dietary coconut oil inhibits GI colonization by C. albicans.

DNase and proteinase K treatment of WT R2866 and R2866ΔampG gene deletion mutant biofilms. DNase and proteinase K treatment of WT R2866 and R2866ΔampG.

PHs of olive brines. pHs of olive brines. The average ± standard deviation (SD) of two independent replicates at each time point is shown. Acetic acid.

Comparative effect of anti-TIM3 against experimental tumors.

Distribution of selected traits across the >4,000 strains in the most recent version of the database, including cell shape (A), spore formation (B), motility.

Impact of IFNγ in B16 melanoma metastasis.

d-Serine utilization contributes to P

Pseudomonas PIV enhances pneumococcal pneumonia and bacteremia in C57BL/6 mice. Pseudomonas PIV enhances pneumococcal pneumonia and bacteremia in C57BL/6.

P. aeruginosa PIV and S. pneumoniae producing pneumolysin induce massive neutrophil recruitment and lung damage during active murine pneumonia. P. aeruginosa.

Transgenic mice with constitutively active NIK show increased tumor growth in bone. Transgenic mice with constitutively active NIK show increased tumor.

BV6 increases bone metastasis.

Distinct antibiotic pretreatments have differential impacts on C

Effect on the recall response of Nrp1 deletion before infection.

Presentation transcript:

De novo prions are infectious. De novo prions are infectious. (A) Photo of one mouse representative of TgCerPrP mice inoculated with de novo prions afflicted with terminal CWD. Note the hind limbs extended behind the mouse, indicating paralysis. (B) TgCerPrP mice inoculated with de novo prions died from terminal disease at a median of 300 dpi, while WT mice remained disease free for the rest of their lives (>500 dpi). TgCerPrP mice inoculated with D10 died approximately 50 days earlier, while TgCerPrP mice inoculated with sPMCA-adapted prions and WT mice inoculated with RML prions died over 100 days earlier. Crystal Meyerett-Reid et al. mSphere 2017; doi:10.1128/mSphere.00372-16