De novo prions are infectious.

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De novo prions are infectious. De novo prions are infectious. (A) Photo of one mouse representative of TgCerPrP mice inoculated with de novo prions afflicted with terminal CWD. Note the hind limbs extended behind the mouse, indicating paralysis. (B) TgCerPrP mice inoculated with de novo prions died from terminal disease at a median of 300 dpi, while WT mice remained disease free for the rest of their lives (>500 dpi). TgCerPrP mice inoculated with D10 died approximately 50 days earlier, while TgCerPrP mice inoculated with sPMCA-adapted prions and WT mice inoculated with RML prions died over 100 days earlier. Crystal Meyerett-Reid et al. mSphere 2017; doi:10.1128/mSphere.00372-16