The National Institutes of Allergy and Infectious Diseases networks on asthma in inner- city children: An approach to improved care William W. Busse,

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The National Institutes of Allergy and Infectious Diseases networks on asthma in inner- city children: An approach to improved care William W. Busse, MD Journal of Allergy and Clinical Immunology Volume 125, Issue 3, Pages 529-537 (March 2010) DOI: 10.1016/j.jaci.2010.01.036 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A comparison of the effects of addition of nitric oxide (NO) monitoring and guideline-directed care with guideline-directed care alone on maximum number of days with symptoms. During the run-in period, the patients' asthma treatment was adjusted before entering the control versus the NO-monitoring group. Reprinted with permission from Szefler et al.21 Journal of Allergy and Clinical Immunology 2010 125, 529-537DOI: (10.1016/j.jaci.2010.01.036) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Urgent health care use increased with disease severity. Data are shown as lifetime (ever) events and visits in the past year. Hosp, Inpatient hospitalizations; Vent, need for mechanical ventilation. White bars, Mild asthma (n = 5,164); hatched bars, moderate asthma; black bars, severe asthma. ∗P < .0001, all groups are different from each other; †P < .0001, mild and moderate groups are similar but different from the severe group. Reprinted with permission from Moore et al.32 Journal of Allergy and Clinical Immunology 2010 125, 529-537DOI: (10.1016/j.jaci.2010.01.036) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 A multiplicity of environmental factors influence the development of asthma and the resulting phenotype. The resulting phenotypes will also have variable levels of severity, which, in turn, will influence the response to treatment and eventual asthma control. Journal of Allergy and Clinical Immunology 2010 125, 529-537DOI: (10.1016/j.jaci.2010.01.036) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions