Thomas Münzel et al. JACC 2018;71:

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Thomas Münzel et al. JACC 2018;71:688-697 Adverse Cardiovascular Effects of Aircraft Noise Exposure in Mice Noise increases systolic blood pressure (A, orange), impairs endothelial function (B), reduces vascular nitric oxide levels (measured by electron paramagnetic resonance spectroscopy) (arrows indicate nitrosyl-iron triplet signal) (C), and enhances sensitivity to vasoconstrictors (D). (E and F) Noise causes substantial vascular 3-nitrotyrosine staining. (G and H) Noise increases vascular autocrine endothelin-1 production. Stainings reflect representative immunohistochemistry images. Brown color indicates nitrotyrosine or endothelin-1 staining. ∗p < 0.05 versus group without noise (CTR or WT). Adapted from Münzel et al. (24) with permission of the publisher. Copyright © 2017, Oxford University Press. CTR = control; ET-1 = endothelin-1; NO = nitric oxide; WT = wild-type. Thomas Münzel et al. JACC 2018;71:688-697 2018 The Authors