(fold of TGF-β1 response)

Slides:

Advertisements

Similar presentations

A B Supplementary Figure 1: A, TRAIL-induced apoptosis in melanoma cells and melanocytes. Cells were treated with TRAIL (200ng/ml) for 24 hours before.

Advertisements

Figure 3. CSE increases the production of IL-8 in A549 cells

Supplementary Figure S4

IL-18 Downregulates Collagen Production in Human Dermal Fibroblasts via the ERK Pathway Hee Jung Kim, Seok Bean Song, Jung Min Choi, Kyung Moon Kim,

Takehiko Wada, Jeffrey W. Pippin, Yoshio Terada, Stuart J. Shankland

Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells Chiara Laezza, Alba D’Alessandro, Simona Paladino, Anna.

Figure 3. Elevation of p53 and its acetylation after treatment with FK866 and nicotinamide adenine dinucleotide (NAD+). Cells were treated for 72 hours.

Supplemental Figure 2 A B vehicle

Volume 355, Issue 2, Pages (December 2014)

Volume 126, Issue 3, Pages (March 2004)

From: β-Catenin/CBP–Dependent Signaling Regulates TGF-β–Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells Invest. Ophthalmol. Vis.

A B C MDA-MB-231 OHT: h FOXM1 PLK CDC25b ERα Tubulin

A B C D Supplementary Figure 1 CMV p300

Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria Dan Wang, Chunsun Dai, Yingjian Li, Youhua.

Volume 41, Issue 2, Pages (August 2004)

STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma by Christine Brender, Mette Nielsen, Keld Kaltoft, Gitte Mikkelsen, Qian.

TGF-β1 induces ILK activity in renal tubular epithelial cells.

Inhibition of ILK restores epithelial ZO-1 and E-cadherin and inhibits fibronectin and Snail1 expression after TGF-β1 treatment. Inhibition of ILK restores.

Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells W. Qi, X. Chen, S. Twigg, T.S. Polhill,

Resveratrol Targets Transforming Growth Factor-β2 Signaling to Block UV-Induced Tumor Progression Kwang Ho Kim, Jung Ho Back, Yucui Zhu, Josh Arbesman,

Small-molecule inhibitor QLT-0267 suppresses ILK activity and inhibits its downstream signaling. Small-molecule inhibitor QLT-0267 suppresses ILK activity.

GM-CSF induces tumor cell EMT and stemness.

NF-κBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1β-induced and TNF-α-induced chondrocytes Dr C. Lianxu, Ph.D.,

Histone deacetylase inhibitors suppress interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes N. Chabane, M.Sc.,

Mycophenolic Acid Inhibits Natural Killer Cell Proliferation and Cytotoxic Function: A Possible Disadvantage of Including Mycophenolate Mofetil in the.

Volume 18, Issue 11, Pages (November 2011)

Identifying Inhibitors of Epithelial-Mesenchymal Transition by Connectivity Map–Based Systems Approach Ajaya Kumar Reka, PhD, Rork Kuick, MS, Himabindu.

Anti-apoptotic effect of transforming growth factor-β1 on human articular chondrocytes: role of protein phosphatase 2A M. Lires-Deán, B.S., B. Caramés,

Expression and Function of RIG-I in Oral Keratinocytes and Fibroblasts

Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated.

Volume 16, Issue 4, Pages (October 2009)

Role of Bcl-xL in paracetamol-induced tubular epithelial cell death

Short-chain fatty acids induce cell cycle inhibitors in colonocytes

Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation A.

Andreea M. Bujor, Jaspreet Pannu, Shizhong Bu, Edwin A. Smith, Robin C

PDGFRα GBM primary cultures demonstrate titratable and temporal DOX-inducible expression of hPDGF-A and receptor activation. PDGFRα GBM primary cultures.

Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor β-3 Doina S. Joseph, M.S., Minnie Malik, Ph.D., Sahadat.

Transforming growth factor (TGF)-β1-induced human endometrial stromal cell decidualization through extracellular signal-regulated kinase and Smad activation.

Isoliquiritigenin Inhibits IL-1β-Induced Production of Matrix Metalloproteinase in Articular Chondrocytes Lei Zhang, Shiyun Ma, Hang Su, Jiaxiang Cheng

Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes A.W.M. Cheng,

1,25-dihydroxyvitamin D3 inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression Yingjian Li, Bradley C.

Profiling Motility Signal-Specific Genes in Primary Human Keratinocytes Chieh-Fang Cheng, Jianhua Fan, Balaji Bandyopahdhay, Dennis Mock, Shengxi Guan,

Implication of prostaglandin E2 in TNF-α-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs K. Fushimi,

Regulated P124SMEK1 expression cannot alter p-ERK levels or sensitivity to BRAF or MEK inhibition in V600EBRAF melanoma cell lines. Regulated P124SMEK1.

Kellie J. White, Vincent J. Maffei, Marvin Newton-West, Robert A

Volume 138, Issue 4, Pages (April 2010)

Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells Gur P. Kaushal, Varsha Kaushal, Ph.D., Xiaoman.

Volume 85, Issue 2, Pages (January 2014)

IL-18 Downregulates Collagen Production in Human Dermal Fibroblasts via the ERK Pathway Hee Jung Kim, Seok Bean Song, Jung Min Choi, Kyung Moon Kim,

Collagen Synthesis Is Suppressed in Dermal Fibroblasts by the Human Antimicrobial Peptide LL-37 Hyun Jeong Park, Dae Ho Cho, Hee Jung Kim, Jun Young.

Leto et al., Supplementary Figure S3

Role of Bcl-xL in paracetamol-induced tubular epithelial cell death

Nef Triggers a Transcriptional Program in T Cells Imitating Single-Signal T Cell Activation and Inducing HIV Virulence Mediators Alison Simmons, Varuna.

Supplementary Figure 1 A B C SW620 HT29 SW620

Volume 60, Issue 3, Pages (September 2001)

Volume 83, Issue 5, Pages (November 2002)

Volume 70, Issue 5, Pages (September 2006)

Pharmacologic inhibition of eIF5A hypusination sensitizes KRas-driven tumor cells to MEK and KRas inhibition. Pharmacologic inhibition of eIF5A hypusination.

(fold of TGF-β1 response)

Fig. 3. Relative expression levels of ASNS to α-tubulin were dramatically increased when treating human cells with nocodazole and ASNase. Relative expression.

Leptin and amylin signaling.

IL-6 inhibits insulin-induced formation of p85/IRS-1 complexes.

Synergistic WNT1 and WNT7B signaling is downstream of LRP6 phosphorylation and β-catenin stabilization. Synergistic WNT1 and WNT7B signaling is downstream.

Raghvendra Singh, Stelios T Andreadis Molecular Therapy

Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells Yuzhi Hong, Wuding Zhou, Ke Li,

JAK inhibitors suppress IL-17–induced expression of IκB-ζ.

TGF-β1 modulates extracellular matrix–mediated MT1-MMP expression.

Changes in signal transduction pathway induced by gefitinib.

FGFR1 is dominantly expressed in mesenchymal-like KRAS-mutant lung cancer cell lines. FGFR1 is dominantly expressed in mesenchymal-like KRAS-mutant lung.

Combined inhibition of coamplified RTKs is required for response.

Presentation transcript:

(fold of TGF-β1 response) E-cadherin β-tubulin TGF-β1 CsA (μM) - 5 10 + Cyclosporin A (μM) None (fold of TGF-β1 response) 1.0 2.0 FK506 (μM) (A) (B) 3.0 CsA inhibited TGF-β1-induced decreases in E-cadherin expression. A549 cells were treated with 10 ng/mL TGF-β1 for 48 h in the presence of the indicated concentrations of CsA (A) and FK506 (B). Cell lysates were subjected to Western blotting for E-cadherin and β-tubulin. In A, quantitative data for E-cadherin levels are expressed as fold changes from the TGF-β1 response without CsA. Data are means ± S.E. from three independent experiments. In B, a representative blot from three independent experiments is shown. +P<0.05, significantly different from the TGF-β1-alone response. Figure S2