Angiotensin-(1-7) activates the IGF-1/Akt signalling pathway during muscle disuse through the Mas receptor. Angiotensin-(1-7) activates the IGF-1/Akt signalling.

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Angiotensin-(1-7) activates the IGF-1/Akt signalling pathway during muscle disuse through the Mas receptor. Angiotensin-(1-7) activates the IGF-1/Akt signalling pathway during muscle disuse through the Mas receptor. The hind limb of wild-type (WT) and Mas knockout (KO) mice in the presence or absence of Ang-(1-7) were unilaterally immobilized for 14 days. The tibialis anterior (TA) from (A) WT and (C) Mas KO mice were isolated and homogenized to evaluate the protein levels of phosphorylated Akt, FoxO3 and p70S6K via western blot. The total levels of Akt, FoxO3 and p70S6K were used as the loading control. Molecular mass markers are shown in kilodaltons. (B,D) Quantitative analysis of the experiments from A and C, respectively. The levels of phospho-protein normalized to total protein are expressed relative to the vehicle-treated/non-immobilized TA and correspond to the mean±s.d. from three independent experiments. In each experiment, five to seven mice were used for each experimental condition. *P<0.05 vs vehicle-treated/non-immobilized TA; #P<0.05 vs vehicle-treated/immobilized TA. María Gabriela Morales et al. Dis. Model. Mech. 2016;9:441-449 © 2016. Published by The Company of Biologists Ltd