Cross-validation between centres for inbred mice.

Slides:



Advertisements
Similar presentations
Mitochondria localize to both the front and the rear of neutrophils.
Advertisements

SESN2 expression in lungs from healthy donors, habitual smokers without COPD and individuals with late-stage COPD. (A) Representative western blots of.
pkd1a/b and pkd2 interact in axial morphogenesis.
Azithromycin treatment eliminates NTHi infection.
Representative illustrations of a sagittal lung section stained with H&E in a control and a CS-exposed mouse after 6 months. Representative illustrations.
Loss of RBP-J results in a reduction of segments due to total branch loss with age. Loss of RBP-J results in a reduction of segments due to total branch.
Total and differential cell counting in the broncho-alveolar lavage of mice exposed to CS or air during 3 or 6 months. Total and differential cell counting.
Representative histological images of aorta from WT, ApoEm/m and ApoE−/− pigs. Representative histological images of aorta from WT, ApoEm/m and ApoE−/−
Alterations in Notch signaling affect the frequency of intermediate and main IHBD branches. Alterations in Notch signaling affect the frequency of intermediate.
OA and related amines modulate motility and length of schistosomula.
MicroCT analysis reveals that IHBD average volume is modulated with age upon deletion of RBP-J or activation of Notch1. MicroCT analysis reveals that IHBD.
Effects of embryonic hypoxia on fasted and postprandial cardiac shunting. Effects of embryonic hypoxia on fasted and postprandial cardiac shunting. Mean.
Tomoregulin-1 improves cardiac morphology and function after pressure overload. Tomoregulin-1 improves cardiac morphology and function after pressure overload.
Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.
Discordance and similarity between humans with FA and FA mouse models.
Fig. 2. Body weight and size analysis of A1/A2-KO mice
Molecular profiles of lung, and of blood and plasma in M
Crotonate increases histone crotonylation in mouse kidney.
Concentration of biomarkers of haemostasis.
TP53 western blot of primary cultured tail cells from both wild-type (WT) and Tp53Δ11/Δ11 (−/−) rats. TP53 western blot of primary cultured tail cells.
Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.
Tomoregulin-1 inhibits the TGFβ non-canonical (TAK1-JNK) pathways after pressure overload. Tomoregulin-1 inhibits the TGFβ non-canonical (TAK1-JNK) pathways.
Erythroid progenitor capacity of Epo transgenic mice.
Survival and telomere length of G2tert−/− zebrafish in a p53−/− background. Survival and telomere length of G2tert−/− zebrafish in a p53−/− background.
Pie charts showing the percentage of genes for selected enriched biological functions and pathways at different time points after hyperthermic seizures.
Fig. 7. E2F1 acetylation in A1/A2-KO MEFs
Latency to onset of Stage III behavioral seizure activity.
TWEAK downregulates SIRT3 in cultured tubular cells and this is prevented by crotonate. TWEAK downregulates SIRT3 in cultured tubular cells and this is.
Behavioral test parameters.
Fig. 3. Lifetime fecundity and fecundity across age blocks in flies from the selected and control populations emerging in the morning and evening windows.(a)
Obesity affected the metabolic response to stroke.
Effects of tumour size on response to treatment in the KPC model.
Expression data confirm and extend existing knowledge
Factors affecting standardization of rodent impact TBI models.
Silencing of Keap1 reduced the expression of inflammatory markers in ConA-injected livers. Silencing of Keap1 reduced the expression of inflammatory markers.
Immobilization decreases the global rates of protein synthesis and muscle mass, but activates mTOR signaling and cap-dependent translation. Immobilization.
Treatment of HCMT-CMs with bisoprolol.
Superimposed traces representing the effects of different concentrations of adrenaline on AP characteristics. Superimposed traces representing the effects.
Tamoxifen injections induce DNA damage response signaling in αMHC-MerCreMer mice.αMHC-MerCreMer+/+ mice received an injection of 60 μg/g body weight of.
Tamoxifen injections in αMHC-MerCreMer mice induce a loxP-independent DNA damage response, leading to myocardial dysfunction and death. Tamoxifen injections.
Elevated expression of vegfaa in hemangiosarcoma.
Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs. Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs.
Distribution and extent of expression.
Intestinal CAV1 deletion alters circulating FFAs but not TGs
Functional classification and visualization of differentially expressed genes. Functional classification and visualization of differentially expressed.
The genomic distribution of essential and non-essential mouse genes, separated into known and predicted essentiality. The genomic distribution of essential.
Biphasic ambulatory activity and reduced avoidance in Id2−/− mice.
Chronic phenytoin increases activity levels in Mecp2Null/Y mice.
2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft. 2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft.
Expression of transgenic IGF-1Ea propeptide in the skin increases local Treg cell numbers. Expression of transgenic IGF-1Ea propeptide in the skin increases.
Tissue ATP levels measured in the liver, muscle, kidney and pancreas of CDs/y and CDr/y on RD or DD. *P
Nerve conduction slowing and DRG sensory neuron and nuclear atrophy in 16-week-old diabetic mice. Nerve conduction slowing and DRG sensory neuron and nuclear.
Food-additive exposure reduces adult fly survival under some feeding conditions. Food-additive exposure reduces adult fly survival under some feeding conditions.
Anti-epileptic drugs with Na+ channel blocking activity improve QTc in individuals with Rett syndrome. Anti-epileptic drugs with Na+ channel blocking activity.
Guinea pigs fed HFHC diet develop impaired glucose tolerance and suppressed response to insulin. Guinea pigs fed HFHC diet develop impaired glucose tolerance.
Therapeutic delivery of rhIGF-1 reduces the severity of contact hypersensitivity responses. Therapeutic delivery of rhIGF-1 reduces the severity of contact.
The amount of PGE2 released by osteoblastic cells was greatest when the cells were treated with serum collected in the post-hibernation period (N=9). The.
Infection did not affect dendritic length of pyriform cortex, thus precluding a generalized retraction all over the brain. Infection did not affect dendritic.
Ankle marker vertical position versus time data just prior to touchdown and during the initial ground contact phase for a representative rear-foot strike.
Examples of tumors represented in Tp53Δ11/Δ11 and Tp53Δ11/+ rats.
ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. (A,B)
The complexity as well as the total dendritic length of ApoE-deficient adult-born granule cells are significantly reduced. The complexity as well as the.
Marginal means (±s.e.m.) of temperatures for four tissues in 13 king penguins while fasting in water. Marginal means (±s.e.m.) of temperatures for four.
Peroxisome speeds were slower in patient and control cells.
Summary of variabilities in hiPSC-CMs.
Effects of paclitaxel and vinblastine.
Effect of siRNA transfection on colony formation by Renca cells.
Graphical representation of pain levels versus time postinjury, annotated across control, persistently hypersensitive genotypes and diabetic conditions,
Functional and molecular regeneration in mdx muscle with matrix treatment. Functional and molecular regeneration in mdx muscle with matrix treatment. (A,B)
Regulation of Bcl-2 family proteins in the hypothalamus of non-diabetic and diabetic IRS2−/− mice. Regulation of Bcl-2 family proteins in the hypothalamus.
Presentation transcript:

Cross-validation between centres for inbred mice. Cross-validation between centres for inbred mice. (A) Total running distance in nightly activity of week 2 (standard wheel). 129 versus B6N, B6J, P<0.0005 and P<0.05, respectively; C3H versus B6N, P<0.01 (Fisher’s post-hoc test). (B) Average run duration in night activity of week 3 (complex wheel). C3H versus all P<0.0001; B6J versus B6N, 129, P<0.005 (Fisher’s post-hoc test). Data are group mean ± s.e.m. collected at CNR and MRC. Silvia Mandillo et al. Dis. Model. Mech. 2014;7:397-407 © 2014. Published by The Company of Biologists Ltd