Seasonal intestinal inflammation in patients with birch pollen allergy

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Presentation transcript:

Seasonal intestinal inflammation in patients with birch pollen allergy Jenny Magnusson, PhDad, Xiao Ping Lin, MDb, Anna Dahlman-Höglund, PhDc, Lars Å. Hanson, MD, PhDb, Esbjörn Telemo, PhDd, Olle Magnusson, MD, PhDe, Ulf Bengtsson, MD, PhDa, Staffan Ahlstedt, PhDf Journal of Allergy and Clinical Immunology Volume 112, Issue 1, Pages 45-51 (July 2003) DOI: 10.1067/mai.2003.1604 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Numbers of MBP+ eosinophils (A) , IgE stained cells (B) , CD3+ T cells (C) in duodenal biopsy specimens taken from patients with birch pollen allergy and healthy control subjects in season and off-season (n = 9). Results are expressed as individual data points and the median is indicated. *P < .05. **P < .005. ***P < .001. Journal of Allergy and Clinical Immunology 2003 112, 45-51DOI: (10.1067/mai.2003.1604) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Immunostaining of duodenal biopsy specimens from patients with birch pollen allergy and control subjects. Red-brown color indicates positive staining; blue color is counterstaining of nuclei. Black bars indicate 30 μm. (A) Marked increase of MBP-stained eosinophils in a patient during the birch pollen season; (B) MBP+ cells in a patient off-season; (C) MBP-stained eosinophils in a healthy control subject; (D) enhanced presence of IgE-stained cells in a patient during birch pollen season; (E) presence of IgE-stained cells in a patient off-season; (F) IgE-stained cells in a healthy control subject; (G) isotype control staining. Journal of Allergy and Clinical Immunology 2003 112, 45-51DOI: (10.1067/mai.2003.1604) Copyright © 2003 Mosby, Inc. Terms and Conditions