Anti-RNP/anti-Sm antibodies in sera (bleeds 1–5) and H&E stained sections of kidney/salivary gland of the MRL-lpr/lpr and MRL-MpJ mice provided with water,

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Anti-RNP/anti-Sm antibodies in sera (bleeds 1–5) and H&E stained sections of kidney/salivary gland of the MRL-lpr/lpr and MRL-MpJ mice provided with water, CU or TU. (aA) Anti-RNP and anti-Sm in sera of the lpr-water, lpr-CU and lpr-TU groups of mice. Anti-RNP/anti-Sm antibodies in sera (bleeds 1–5) and H&E stained sections of kidney/salivary gland of the MRL-lpr/lpr and MRL-MpJ mice provided with water, CU or TU. (aA) Anti-RNP and anti-Sm in sera of the lpr-water, lpr-CU and lpr-TU groups of mice. (aB) Anti-RNP and anti-Sm in sera of the MpJ-water, MpJ-CU and MpJ-TU groups of mice. Values for each bleed were normalised to an anti-Sm or anti-RNP-positive control. Values are given as means±SD for each group. Statistical analyses were done by Student's t test and the p-value was arrived at to assess the statistical significance of the changes observed. p<0.05 or lower was considered to be significant; (b) kidney and salivary gland histopathology. (A) lpr-water, (B) lpr-CU (C) lpr-TU and (D) control MpJ mice. Protein casts in kidney and cellular infiltrates in salivary gland are indicated by arrows. CU, curcumin; RNP, ribonucleoprotein; TU, turmeric. Biji T Kurien et al. Lupus Sci Med 2015;2:e000114 ©2015 by Lupus Foundation of America