Multiplex Ligation-Dependent Probe Amplification Identification of Whole Exon and Single Nucleotide Deletions in the CFTR Gene of Hispanic Individuals.

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Multiplex Ligation-Dependent Probe Amplification Identification of Whole Exon and Single Nucleotide Deletions in the CFTR Gene of Hispanic Individuals with Cystic Fibrosis Iris Schrijver, Krista Rappahahn, Lynn Pique, Martin Kharrazi, Lee-Jun Wong The Journal of Molecular Diagnostics Volume 10, Issue 4, Pages 368-375 (July 2008) DOI: 10.2353/jmoldx.2008.080004 Copyright © 2008 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 Peak pattern of three suspected exon deletions in CFTR. A 35 to 50% reduction of relative peak height of the amplified product (compared to a corresponding control) suggested two apparently novel deletions in three patients: deletion of exon 6b (two subjects) and deletion of exon 20. The Journal of Molecular Diagnostics 2008 10, 368-375DOI: (10.2353/jmoldx.2008.080004) Copyright © 2008 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions