Life-Threatening Dextromethorphan Intoxication Associated with Interaction with Amitriptyline in a Poor CYP2D6 Metabolizer: A Single Case Re-Exposure.

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Life-Threatening Dextromethorphan Intoxication Associated with Interaction with Amitriptyline in a Poor CYP2D6 Metabolizer: A Single Case Re-Exposure Study Patrice Forget, MD, Bernard le Polain de Waroux, MD, Pierre Wallemacq, MD, PhD, Jean-Luc Gala, MD, PhD Journal of Pain and Symptom Management Volume 36, Issue 1, Pages 92-96 (July 2008) DOI: 10.1016/j.jpainsymman.2007.09.006 Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Plasma concentrations (ng/mL) of drugs. All concentrations remained stable except for dextromethorphan, which rapidly rose on Days 2 and 3. Journal of Pain and Symptom Management 2008 36, 92-96DOI: (10.1016/j.jpainsymman.2007.09.006) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions