Renal actions of synthetic Dendroaspis natriuretic peptide

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Renal actions of synthetic Dendroaspis natriuretic peptide Ondrej Lisy, Michihisa Jougasaki, Denise M. Heublein, John A. Schirger, Horng H. Chen, Paul W. Wennberg, John C. Burnett Kidney International Volume 56, Issue 2, Pages 502-508 (August 1999) DOI: 10.1046/j.1523-1755.1999.00573.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Amino acid sequence and structure of Dendroaspis natriuretic peptide. The amino acid sequence was originally reported by Schweitz et al9. Kidney International 1999 56, 502-508DOI: (10.1046/j.1523-1755.1999.00573.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Plasma Dendroaspis natriuretic peptide (PDNP; A) and urinary DNP excretion (UDNPV; B). Abbreviations are: Baseline, baseline 30-minute clearance; DNP-10, 30-minute clearance with 10 ng/kg intravenous infusion of DNP; DNP-50, 30-minute clearance with 50 ng/kg intravenous infusion of DNP; Recovery, 30-minute clearance after a 150-minute washout period. Repeated-measures analysis of variance followed by post hoc Bonferroni test was used for statistical comparisons between clearances. *P < 0.05 vs. Baseline; †P < 0.05 vs. DNP-10; ‡P < 0.05 vs. DNP-50. Kidney International 1999 56, 502-508DOI: (10.1046/j.1523-1755.1999.00573.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Humoral and renal responses to Dendroaspis natriuretic peptide (DNP) administration. Abbreviations are: Baseline, baseline 30-minute clearance; DNP-10, 30-minute clearance with 10 ng/kg intravenous infusion of DNP; DNP-50, 30-minute clearance with 50 ng/kg intravenous infusion of DNP; Recovery, 30-minute clearance after a 150-minute washout period. A repeated measures analysis of variance followed by post hoc Bonferroni test was used for statistical comparisons between clearances. *P < 0.05 vs. Baseline; †P < 0.05 vs. DNP-10; ‡P < 0.05 vs. DNP-50. Kidney International 1999 56, 502-508DOI: (10.1046/j.1523-1755.1999.00573.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 Immunohistochemical staining for DNP-like peptide in the canine atrium. Representative sample of atrial myocardium from 10 normal dogs not exposed to exogenous DNP. NGS means normal goat serum (original magnification, ×400). Kidney International 1999 56, 502-508DOI: (10.1046/j.1523-1755.1999.00573.x) Copyright © 1999 International Society of Nephrology Terms and Conditions