Inhaled β2 -agonists and airway responses to allergen

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Presentation transcript:

Inhaled β2 -agonists and airway responses to allergen Donald W. Cockcroft, MD, FRCP(C) Journal of Allergy and Clinical Immunology Volume 102, Issue 5, Pages S96-S99 (November 1998) DOI: 10.1016/S0091-6749(98)70038-7 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Tolerance to the bronchoprotective effect of inhaled β2 -agonists. Left panel shows tolerance to the bronchoprotective effect of terbutaline versus methacholine and AMP, and right panel shows tolerance to the bronchoprotective effect of salbutamol versus methacholine and allergen. The vertical axis represents the bronchoprotection expressed as doubling-dose change in PC20 immediately after administration of the inhaled β2 -agonist compared with that before. The horizontal axis notes before and after regular 4 times daily use of the β2 -agonist. (Left panel from O’Connor BJ et al. N Engl J Med 1992;327:1204-8.) (Right panel modified from Cockcroft DW, et al. Laneet 1993; 342:833-7, Fig 2.) Journal of Allergy and Clinical Immunology 1998 102, S96-S99DOI: (10.1016/S0091-6749(98)70038-7) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Methacholine PC20 and allergen PC20 before and after 200 μg salbutamol during the 2 treatment periods. Results (n = 12) are expressed as the dose shift (mean ± SEM) calculated as Δ log10 PC20 ÷ 0.3. Baseline PC20 values during placebo treatment period are arbitrarily defined as 0. SE bars at bottom of 2 salbutamol treatment period bars represent dose shift compared with placebo period (methacholine, 0 [0.18]; allergen, 0.91 [0.20]). (From Cockcroft DW et al. Lancet 1993;342:833-7) . Journal of Allergy and Clinical Immunology 1998 102, S96-S99DOI: (10.1016/S0091-6749(98)70038-7) Copyright © 1998 Mosby, Inc. Terms and Conditions