Platelet-released serotonin contributes to hypothermia in mice undergoing HA-hIgG–dependent anaphylaxis. Platelet-released serotonin contributes to hypothermia.

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Platelet-released serotonin contributes to hypothermia in mice undergoing HA-hIgG–dependent anaphylaxis. Platelet-released serotonin contributes to hypothermia in mice undergoing HA-hIgG–dependent anaphylaxis. (A) Releasates (Rel.) from HA-hIgG–activated washed platelets from hFcγRIIAtg mice left untreated (black squares, n = 6) or treated with PCPA (red squares, n = 8) or HA-hIgG–containing TyAlb alone (open squares, n = 9) were transferred intravenously into FcγRnull mice, and changes in body temperature were recorded. (B) Changes in body temperature during HA-hIgG–dependent anaphylaxis in hFcγRIIAtg (circles) and FcγRnull (squares) mice, pretreated with PCPA (black symbols, n ≥ 8) or vehicle control (open symbols, n ≥ 8). (C) Platelet counts from the experiment represented in (B) 70 min after anaphylaxis induction. (D) Changes in body temperature in WT mice injected intravenously with 0 (n = 4), 20 (n = 3), or 100 μg (n = 3) of serotonin. Data are representative of three independent experiments. (A to C) Data are pooled from three (A) or two (B and C) independent experiments. *P < 0.05, **P < 0.01, and ****P < 0.0001. Héloïse Beutier et al. Sci. Immunol. 2018;3:eaan5997 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works