Comparison of the regression lines for AIRarg (the acute insulin response to intravenous arginine over 2–5 min after injection) and AIRargMAX (the response.

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Presentation transcript:

Comparison of the regression lines for AIRarg (the acute insulin response to intravenous arginine over 2–5 min after injection) and AIRargMAX (the response to arginine after 60 min of an intervening intravenous glucose infusion, which is known to potentiate AIRarg to a maximum response) for autoislets and previously published data for alloislets transplanted in T1D recipients. Comparison of the regression lines for AIRarg (the acute insulin response to intravenous arginine over 2–5 min after injection) and AIRargMAX (the response to arginine after 60 min of an intervening intravenous glucose infusion, which is known to potentiate AIRarg to a maximum response) for autoislets and previously published data for alloislets transplanted in T1D recipients. (Line 15: Ryan et al. Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes 2002;51:2148–2157. Line 16: Rickels et al. β-Cell secretory capacity and demand in recipients of islet, pancreas, and kidney transplants. J Clin Endocrinol Metab 2010;95:1238–1246.) The regression lines for the alloislets were less steep and had smaller slopes than the autoislets. Adapted with permission from Robertson et al. (32). R. Paul Robertson Dia Care 2015;38:1030-1035 ©2015 by American Diabetes Association