Reduced Skin Capillary Density During Attacks of Erythromelalgia Implies Arteriovenous Shunting as Pathogenetic Mechanism  Cato Mørk  Journal of Investigative Dermatology  Volume 119, Issue 4, Pages 949-953 (October 2002) DOI: 10.1046/j.1523-1747.2002.00218.x Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Postulated pathogenetic mechanism of EM. Journal of Investigative Dermatology 2002 119, 949-953DOI: (10.1046/j.1523-1747.2002.00218.x) Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Capillary density was significantly reduced in EM patients after central body heating in the nail bed area with the highest concentration of AV shunts. (a) EM patients and (b) healthy control group. The reduction in capillary density was significantly higher in EM patients in the nail bed area () compared to the control group (*p <0.05), in contrast to the foot arch (□). Journal of Investigative Dermatology 2002 119, 949-953DOI: (10.1046/j.1523-1747.2002.00218.x) Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Capillary density was significantly reduced in EM patients after central body heating in the nail bed area with the highest concentration of AV shunts. (a) EM patients and (b) healthy control group. The reduction in capillary density was significantly higher in EM patients in the nail bed area () compared to the control group (*p <0.05), in contrast to the foot arch (□). Journal of Investigative Dermatology 2002 119, 949-953DOI: (10.1046/j.1523-1747.2002.00218.x) Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 The symptomatic subset of EM patients had more pronounced reduction in capillary density in the nail bed. (a) Symptomatic EM patients; (b) asymptomatic EM patients; and (c) healthy control group. The reduction in capillary density was significantly higher in symptomatic EM patients in the nail bed area () compared to asymptomatic patients and controls after central body heating. No such difference was found between the three groups in the foot arch, (□) but the same nonsignificant trend was observed. Distribution of data is illustrated as box plots, where the boxes show median with quartiles. *p <0.05 and **p <0.01 compared to symptomatic EM in the nail bed area. Journal of Investigative Dermatology 2002 119, 949-953DOI: (10.1046/j.1523-1747.2002.00218.x) Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 The symptomatic subset of EM patients had more pronounced reduction in capillary density in the nail bed. (a) Symptomatic EM patients; (b) asymptomatic EM patients; and (c) healthy control group. The reduction in capillary density was significantly higher in symptomatic EM patients in the nail bed area () compared to asymptomatic patients and controls after central body heating. No such difference was found between the three groups in the foot arch, (□) but the same nonsignificant trend was observed. Distribution of data is illustrated as box plots, where the boxes show median with quartiles. *p <0.05 and **p <0.01 compared to symptomatic EM in the nail bed area. Journal of Investigative Dermatology 2002 119, 949-953DOI: (10.1046/j.1523-1747.2002.00218.x) Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions