Structure of Wt1 genomic regions in human and zebrafish.

Slides:

Advertisements

Similar presentations

Accumulation of transcripts from MULE‐F19G14–CyP40 and transposons in mom1 and ddm1. Accumulation of transcripts from MULE‐F19G14–CyP40 and transposons.

Advertisements

Lisa Edelmann, Raj K. Pandita, Bernice E. Morrow

H/F-LV IS distribution in hCD34+ cells.

Cosuppression in Drosophila: Gene Silencing of Alcohol dehydrogenase by white-Adh Transgenes Is Polycomb Dependent Manika Pal-Bhadra, Utpal Bhadra, James.

Volume 38, Issue 4, Pages (May 2010)

Matthew Adlam, Gerald Siu Immunity

Volume 7, Issue 4, Pages (October 1997)

Volume 10, Issue 1, Pages (July 2002)

EpiQTL mapping of glucosinolate mean and CV

Volume 18, Issue 9, Pages (February 2017)

Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae Anna Azvolinsky, Paul G. Giresi,

Identification of chromosomal regions that exhibit evidence of selection. Identification of chromosomal regions that exhibit evidence of selection. Allele.

Volume 29, Issue 1, Pages (April 2014)

Autosomal-Dominant Microtia Linked to Five Tandem Copies of a Copy-Number- Variable Region at Chromosome 4p16 Irina Balikova, Kevin Martens, Cindy Melotte,

Formation of Chromosomal Domains by Loop Extrusion

Genomic rearrangements of E

Targeted re-sequencing of linkage region on 2q21 identifies a novel functional variant for hip and knee osteoarthritis M. Taipale, E. Jakkula, O.-P.

Human Epidermal Differentiation Complex in a Single 2

The Release 5.1 Annotation of Drosophila melanogaster Heterochromatin

Reversing the TERT promoter mutation to WT reverses the active chromatin marks and alters long-range chromatin interactions. Reversing the TERT promoter.

Volume 10, Issue 8, Pages (March 2015)

Complex Role of TNF Variants in Psoriatic Arthritis and Treatment Response to Anti- TNF Therapy: Evidence and Concepts Ulrike Hüffmeier, Rotraut Mössner

Recurrent 10q22-q23 Deletions: A Genomic Disorder on 10q Associated with Cognitive and Behavioral Abnormalities Jorune Balciuniene, Ningping Feng, Kelly.

Yeast Origins Establish a Strand Bias for Replicational Mutagenesis

RNA Structural Determinants of Optimal Codons Revealed by MAGE-Seq

John D. Rioux, Valerie A. Stone, Mark J

Transposons invade maternal genome in vas, mnk double mutant flies.

Examples for intrachromosomal mRNA co‐regulation patches

N-terminal extension of a gene using peptides mapping upstream to an annotated start site. N-terminal extension of a gene using peptides mapping upstream.

Number of genes/antibodies included in the database.

HOXA10 mutations in congenital absence of uterus and vagina

Validation of ChIP-seq reads.

A DNA Replication Mechanism for Generating Nonrecurrent Rearrangements Associated with Genomic Disorders Jennifer A. Lee, Claudia M.B. Carvalho, James.

insomniac and Cullin-3 Regulate Sleep and Wakefulness in Drosophila

Volume 12, Issue 4, Pages (October 2003)

DNA Looping Facilitates Targeting of a Chromatin Remodeling Enzyme

A multitiered approach to characterize transcriptome structure.

Gene Density, Transcription, and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains Chunhui Hou, Li Li, Zhaohui S.

APOE Gene Targeting (A) Schematic representation of the endogenous APOE locus, the gene targeting vector and the targeted APOE locus. The exons of the.

Volume 7, Issue 2, Pages (August 2010)

Multiple Developmental Stage–Specific Enhancers Regulate CD8 Expression in Developing Thymocytes and in Thymus-Independent T Cells Wilfried Ellmeier,

Identification of the GCS1 ortholog in Gonium pectorale.

Origins and Evolution of tetherin, an Orphan Antiviral Gene

Commissural Wt1+ neurons.

Multiple sequence alignment of STAT6 and other STAT proteins produced by ClusterW and ESpript (espript.ibcp.fr/ESPript/ESPript/). Multiple sequence alignment.

The Effect of Distance on Long-Range Chromatin Interactions

CaQTL analysis identifies genetic variants affecting human islet cis-RE use. caQTL analysis identifies genetic variants affecting human islet cis-RE use.

The conserved region upstream of wt1a is required for its expression in the intermediate mesoderm. The conserved region upstream of wt1a is required for.

A 336 bp regulatory region upstream of wt1b is necessary and sufficient for expression in the pronephric glomeruli. A 336 bp regulatory region upstream.

Reporter gene expression in transgenic zebrafish embryos recapitulates expression of wt1 paralogs. Reporter gene expression in transgenic zebrafish embryos.

Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci Eilis Hannon, Mike Weedon, Nicholas Bray,

Identification of TSIX, Encoding an RNA Antisense to Human XIST, Reveals Differences from its Murine Counterpart: Implications for X Inactivation Barbara.

Alignment of Wt1 genomic regions reveals a highly conserved element upstream of zebrafish wt1a. Alignment of Wt1 genomic regions reveals a highly conserved.

Expression of multiple forms of MEL1 gene products.

Example of swimming trajectories from three groups of fish from three different weeks along with the extracted behavioral parameters. Example of swimming.

The zebrafish ortholog of human JunB is expressed in the zebrafish heart. The zebrafish ortholog of human JunB is expressed in the zebrafish heart. (A)

Volume 11, Issue 7, Pages (May 2015)

Regional plot and genome browser view of 14q13.

Predicted Amino Acid Sequence of the Tomato Cf-4 Protein (Thomas et al

Results from a GWAS of prostate cancer in the KP population (8,399 cases and 38,745 controls), highlighting key chromosomal regions. Results from a GWAS.

Volume 17, Issue 5, Pages (May 2009)

Next-Generation Sequencing of Duplication CNVs Reveals that Most Are Tandem and Some Create Fusion Genes at Breakpoints Scott Newman, Karen E. Hermetz,

Methylation of cytosine and consequences of deamination of methyl-C

ROS Generation, Defense Gene Expression, and Histone Acetylation Levels in the HDT701 OX and RNAi Plants.(A) ROS level in HDT701 RNAi plants after flg22.

Fig. 7. JQ1 represses the enhancer-promoter interaction of BRCA1.

Integrated analysis of gene expression and copy number alterations.

Genome-Edited Triple-Recessive Mutation Alters Seed Dormancy in Wheat

Mutant TERT promoter displays active histone marks and distinct long-range interactions: A, cell lines that were used in the study with their origin and.

Potent and sequence-specific removal through genome targeting with CRISPR-Cas systems. Potent and sequence-specific removal through genome targeting with.

Bruce Rannala, Jeff P. Reeve The American Journal of Human Genetics

Presentation transcript:

Structure of Wt1 genomic regions in human and zebrafish. Structure of Wt1 genomic regions in human and zebrafish. (A) The genomic regions surrounding WT1 on human chromosome 11 and wt1a and wt1b on zebrafish chromosomes 25 and 18, respectively, are shown (modified from the Ensembl genome browser, release 49). Colored boxes represent genes that are syntenic between the human WT1 and the zebrafish wt1a and wt1b loci. Gray boxes represent non-syntenic genes. Genes above the double lines are transcribed in the same direction as Wt1, genes below in the opposite direction. (B) Higher magnifications of the areas indicated by dashed rectangles in A, illustrating the fragments used for the generation of transgenic fish lines. The 5′-to-3′ orientation of the genes is indicated by arrows. The gene marked by an asterisk is predicted by the Ensembl genome browser (gene A2BG01). The function of this gene is not known and no orthologs in other vertebrates were predicted. Black vertical bars indicate restriction enzyme sites. Frank Bollig et al. Development 2009;136:2883-2892 © 2009. © 2009.