The Economic Burden of Hyponatremia: Systematic Review and Meta-Analysis Giovanni Corona, MD, PhD, Corinna Giuliani, MD, Gabriele Parenti, MD, PhD, Giorgio.

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Presentation transcript:

The Economic Burden of Hyponatremia: Systematic Review and Meta-Analysis Giovanni Corona, MD, PhD, Corinna Giuliani, MD, Gabriele Parenti, MD, PhD, Giorgio L. Colombo, MSc, Alessandra Sforza, MD, Mario Maggi, MD, PhD, Gianni Forti, MD, Alessandro Peri, MD, PhD The American Journal of Medicine Volume 129, Issue 8, Pages 823-835.e4 (August 2016) DOI: 10.1016/j.amjmed.2016.03.007 Copyright © 2016 Terms and Conditions

Figure 1 Trial flow diagram. LOS = length of stay. The American Journal of Medicine 2016 129, 823-835.e4DOI: (10.1016/j.amjmed.2016.03.007) Copyright © 2016 Terms and Conditions

Figure 2 Mean duration of hospitalization (95% confidence interval; days) in patients with or without (no) hyponatremia in hospitalized series of subjects (A) or according to the presence of heart failure (B), heart surgery (C), liver diseases (D), pulmonary diseases (E), pediatric patients (F), or combined disease (G). CI = confidence interval. The American Journal of Medicine 2016 129, 823-835.e4DOI: (10.1016/j.amjmed.2016.03.007) Copyright © 2016 Terms and Conditions

Figure 2 Mean duration of hospitalization (95% confidence interval; days) in patients with or without (no) hyponatremia in hospitalized series of subjects (A) or according to the presence of heart failure (B), heart surgery (C), liver diseases (D), pulmonary diseases (E), pediatric patients (F), or combined disease (G). CI = confidence interval. The American Journal of Medicine 2016 129, 823-835.e4DOI: (10.1016/j.amjmed.2016.03.007) Copyright © 2016 Terms and Conditions

Figure 2 Mean duration of hospitalization (95% confidence interval; days) in patients with or without (no) hyponatremia in hospitalized series of subjects (A) or according to the presence of heart failure (B), heart surgery (C), liver diseases (D), pulmonary diseases (E), pediatric patients (F), or combined disease (G). CI = confidence interval. The American Journal of Medicine 2016 129, 823-835.e4DOI: (10.1016/j.amjmed.2016.03.007) Copyright © 2016 Terms and Conditions

Figure 2 Mean duration of hospitalization (95% confidence interval; days) in patients with or without (no) hyponatremia in hospitalized series of subjects (A) or according to the presence of heart failure (B), heart surgery (C), liver diseases (D), pulmonary diseases (E), pediatric patients (F), or combined disease (G). CI = confidence interval. The American Journal of Medicine 2016 129, 823-835.e4DOI: (10.1016/j.amjmed.2016.03.007) Copyright © 2016 Terms and Conditions

Figure 3 Odds ratio (95% confidence interval) for hospital readmission in patients with or without (no) hyponatremia. CI = confidence interval. The American Journal of Medicine 2016 129, 823-835.e4DOI: (10.1016/j.amjmed.2016.03.007) Copyright © 2016 Terms and Conditions

Figure 4 Weighted relationship between serum [Na+] cutoff definition and duration of hospitalization. The American Journal of Medicine 2016 129, 823-835.e4DOI: (10.1016/j.amjmed.2016.03.007) Copyright © 2016 Terms and Conditions

Figure 5 Mean hospitalization cost (95% confidence interval [CI]; US dollars) in patients with or without (no) hyponatremia. The American Journal of Medicine 2016 129, 823-835.e4DOI: (10.1016/j.amjmed.2016.03.007) Copyright © 2016 Terms and Conditions