Fig. 1 Characterization of Suv420h dKO mice.

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Fig. 1 Characterization of Suv420h dKO mice. Characterization of Suv420h dKO mice. (A) Top: H&E stains (20×) of paraffin-embedded sections representative of iBAT. Scale bar, 100 mm. Bottom: Quantification of the mass of iBAT and cross-sectional area (CSA) of brown adipocytes (n = 3, males, 4 weeks old). (B) Mitochondria respiratory rates of isolated mitochondria. BAT from controls and dKO mice was dissected and brown adipocytes were isolated. Then, mitochondria were extracted and used into the O2K oxygraph chambers [mean ± SEM; one-way analysis of variance (ANOVA); *P < 0.05] (n = 6 per genotype). (C) Top: H&E stains (20×) of pgWAT (n = 3, males, 4 weeks old). Scale bar, 100 mm. Bottom: Quantification of the mass of pgWAT (left) and quantification of the cross-sectional area of white adipocytes (right) (n = 3, males, 4 weeks old). (D) Top: Immunohistochemistry for Ucp1 on pgWAT of control and dKO mice. Scale bar, 100 mm. Bottom: Quantification of the percentage of Ucp1-stained area (left) and RT-qPCR analysis of Ucp1 expression levels in control and dKO mice (right) (n = 3, males, 4 weeks old). Values are expressed as mean ± SEM; t test; *P < 0.05; **P < 0.01. Simona Pedrotti et al. Sci Adv 2019;5:eaav1472 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).