Pgc-1α+/− mice show an increased inflammatory response to LPS injection. Pgc-1α+/− mice show an increased inflammatory response to LPS injection. (A) RPE/retina.

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Pgc-1α+/− mice show an increased inflammatory response to LPS injection. Pgc-1α+/− mice show an increased inflammatory response to LPS injection. (A) RPE/retina of Pgc-1α+/− mice exhibit 50% reduced Pgc-1α mRNA expression as compared with WT. (B,C) Basal levels of Tnfα and Infγ expression in WT and Pgc-1α+/− (HET) mice in the absence of LPS injection. (D,E) Mice were injected with LPS (0.5 mg/kg, i.p.) and euthanized 24 h after injection. Eyes were enucleated and RPE/retinas extracted for RNA isolation followed by qPCR for Tnfα (D) and Infγ (E). A higher inflammatory response was observed in the RPE/retina of Pgc-1α+/− mice compared with WT, as shown by increased expression of Tnfα (D) and Infγ (E) (n=3 WT, n=3 Pgc-1α+/−). One-way ANOVA followed by Student's t-test was performed using GraphPad Prism7. Meng Zhang et al. Dis. Model. Mech. 2018;11:dmm032698 © 2018. Published by The Company of Biologists Ltd