Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults Laury J.N. Masthoff,

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Presentation transcript:

Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults Laury J.N. Masthoff, MD, Lars Mattsson, PhD, Laurian Zuidmeer-Jongejan, PhD, Jonas Lidholm, PhD, Kerstin Andersson, PhD, Jaap H. Akkerdaas, PhD, Serge A. Versteeg, BSc, Cristiano Garino, PhD, Yolanda Meijer, MD, Petra Kentie, NP, Astrid Versluis, MSc, Constance F. den Hartog Jager, BSc, Carla A.F.M. Bruijnzeel-Koomen, MD, André C. Knulst, MD, Ronald van Ree, PhD, Els van Hoffen, PhD, Suzanne G.M.A. Pasmans, MD Journal of Allergy and Clinical Immunology Volume 132, Issue 2, Pages 393-399 (August 2013) DOI: 10.1016/j.jaci.2013.02.024 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Composition of the study population and different groups with regard to age (children vs adults), severity (hazelnut allergy with no/subjective vs objective symptoms), and judgment of severity (DBPCFC result vs convincing history). Journal of Allergy and Clinical Immunology 2013 132, 393-399DOI: (10.1016/j.jaci.2013.02.024) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Levels of sensitization to hazelnut extract, rCor a 1, rCor a 8, nCor a 9, rCor a 14, birch pollen extract, rBet v 1, rBet v 2, and CCDs in children and adults with hazelnut allergy with objective and those with no or subjective symptoms. Horizontal bars indicate median levels, and IgE values of less than 0.35 kUA/L were set to 0.34 kUA/L. *P < .05. Journal of Allergy and Clinical Immunology 2013 132, 393-399DOI: (10.1016/j.jaci.2013.02.024) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Receiver operating characteristic curves for IgE to hazelnut extract and individual hazelnut components in regard to discrimination between hazelnut allergy with objective and no or subjective symptoms in children (A) and adults (B) with sensitization to hazelnut. Journal of Allergy and Clinical Immunology 2013 132, 393-399DOI: (10.1016/j.jaci.2013.02.024) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions