Volume 22, Issue 9, Pages (September 2015)

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Volume 22, Issue 9, Pages 1157-1158 (September 2015) Pushing Cancer Cells over the Edge, Following Transcription Where Tin Leads, and Why Bugs Make Antibiotics Chemistry & Biology Volume 22, Issue 9, Pages 1157-1158 (September 2015) DOI: 10.1016/j.chembiol.2015.09.001 Copyright © 2015 Terms and Conditions

Tin is a versatile metal, with numerous uses including, perhaps most famously, for making tin cans. Zhang et al. describe a very unexpected discovery that tin(IV) oxochloride is an inhibitor of eukaryotic general transcription factor TFIID, and moreover that it binds a region of TFIID that is known to be intrinsically disordered. Image credit: M. Kostic. Chemistry & Biology 2015 22, 1157-1158DOI: (10.1016/j.chembiol.2015.09.001) Copyright © 2015 Terms and Conditions

Despite some recent suggestions that bacteria might use antibiotics for mediating cooperation, in addition to their recognized role as bacterial weapons, this is not born out by evidence presented by Abrudan et al., who show that Streptomyces strains use antibiotics to fight each other. Image source: “Battle of Issus” by Albrecht Altdorfer “Battle of Issus” (public domain via Wikimedia Commons). Chemistry & Biology 2015 22, 1157-1158DOI: (10.1016/j.chembiol.2015.09.001) Copyright © 2015 Terms and Conditions