TXNIP and caspase-1 protein levels are increased in the adipose tissue of ob/ob mice. TXNIP and caspase-1 protein levels are increased in the adipose tissue.

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TXNIP and caspase-1 protein levels are increased in the adipose tissue of ob/ob mice. TXNIP and caspase-1 protein levels are increased in the adipose tissue of ob/ob mice. A: Plasma glucose levels in fasted wild-type mice and ob/ob mice (n = 5 per group). B: Western blot images and quantification of TXNIP, procaspase-1 (p45), and active caspase-1 (p35) protein levels in the epididymal adipose tissue of wild-type mice and ob/ob mice (n = 5 per group). C: A glucose tolerance test was done using fasted wild-type and caspase-1−/− animals (n = 5 animals per group). D: An insulin tolerance test was performed in fasted wild-type and caspase-1−/− animals (n = 5 animals per group). *P < 0.05; **P < 0.01 using a Student t test. Tim B. Koenen et al. Diabetes 2011;60:517-524 ©2011 by American Diabetes Association