Major pathways that control muscle fiber size.

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Major pathways that control muscle fiber size. Major pathways that control muscle fiber size. Protein synthesis and degradation are regulated by several different stimuli, which activate multiple signaling pathways, many of which converge at common intermediates and/or crosstalk with one another. Many of the components shown here could be promising therapeutic targets. See the main text for further details. Dotted lines depict pathways whose molecular mechanisms and role in adult skeletal muscle have yet to be completely defined. GR, glucocorticoid receptor. Paolo Bonaldo, and Marco Sandri Dis. Model. Mech. 2013;6:25-39 © 2012. Published by The Company of Biologists Ltd