Schematic summary of ROS signaling on coronary artery malformation in the offspring of pregestational diabetic mice. Schematic summary of ROS signaling.

Slides:

Advertisements

Similar presentations

GLP-1 Effectiveness, Mechanisms of Action and Potential Part 4 of 4.

Advertisements

MENU ΣΤΕΦΑΝΙΑΙΑ ΝΟΣΟΣ ΣΕ ΔΙΑΒΗΤΙΚΟΥΣ ΚΑΙ ΗΛΙΚΙΩΜΕΝΟΥΣ.

Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial- induced signalling and cytokine secretion by.

Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long- term Nitric Oxide Synthase Inhibition by.

Figure 2 Different manifestations of myocardial ischaemia

INT-767 treatment prevents the increase in renal HIF and Glut1 expression and ER stress in diabetic DBA/2J mice. INT-767 treatment prevents the increase.

INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice.

MR1 inhibits anti-MTg autoantibody responses in CD28−/− NOD

FIP200 deficiency alters mitochondria activation and ROS production in T cells. FIP200 deficiency alters mitochondria activation and ROS production in.

Baseline Characteristics

Kaplan–Meier estimates of the incidence of first heart failure hospitalization during follow-up according to the statin category among patients with type.

Dandan Wang et al. BTS 2018;3: Overexpression of miR-24 Ameliorates Diabetic Ischemia/Reperfusion Injury (A) Schematic protocol of miR-24 delivery.

CHAMPION Trial design: Patients with recent hospitalization for heart failure were implanted with a pulmonary artery pressure monitor and randomized so.

Dandan Wang et al. BTS 2018;3: Cardiomyocyte-Specific Knock-In miR-24 Ameliorates Ischemia/Reperfusion Injury (A) Quantitative polymerase chain.

Prevalence of microvascular and macrovascular complications compared between cohort 1 and cohort 2 for subjects with type 2 (A, upper panel) and type 1.

Activated membrane signaling promotes survival in response to radiation. Activated membrane signaling promotes survival in response to radiation. Radiation.

(A) Meta-analysis of repeat revascularisation in randomised trials.

Effects of Pay-for-Performance on the Quality of Primary Care in England Mean Scores for Clinical Quality at the Practice Level for Aspects of Care for.

Romain Gallet et al. BTS 2016;1:14-28

Urine ammonia is highly correlated with plasma K

Cox regression of proportion mortality in the first 8 years for patients with three-vessel disease with a significant difference between the treatment.

Change in 6 min walk distance from baseline to each follow-up time for subjects randomised to CABG and to medical therapy alone. The median change and.

BTG2 regulates gluconeogenic gene expression in diabetic mouse models

Schematic representation of an MR analysis.

Schematic diagram of miRNA regulation of the Hippo signalling pathway with multiple inputs and key interactions with HIF1α. Schematic diagram of miRNA.

Exogenous CRP administration causes fasting hyperglycemia and hyperinsulinemia without altering body composition. Exogenous CRP administration causes fasting.

TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin resistance. TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin.

Ion channels expression and insulin secretion in the pancreatic islets of male offspring. Ion channels expression and insulin secretion in the pancreatic.

Schematic overview of diabetes-associated microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular (cerebrovascular, coronary artery,

Schematic diagram that summarizes the findings of the current study showing that diabetes-induced peroxynitrite inactivates the NGF/TrkA receptor prosurvival.

A: The change of plasma glucose in opioid μ-receptor knockout diabetic mice and wild-type controls receiving an oral intake of metformin (100 mg/kg). A:

GLUT4 LXRE is required for downregulation of adipose GLUT4 mRNA during fasting and diet-induced obesity. GLUT4 LXRE is required for downregulation of adipose.

Late gestational SF exposures alter miR-103/107 expression profiles and their target protein Cav1 in VWAT of offspring mice. Late gestational SF exposures.

IRS-1 and -2 expression in four mesangial cell lines from different D-NOD (A and B) and ND-NOD (C and D) mice. IRS-1 and -2 expression in four mesangial.

Immunoblotting samples (A and F) and densitometric analysis of ASC1 (B and G), NLRP3 (C and H), TNFα (D and I) and Caspase-1 (E and J) expression in the.

Starvation-induced inhibition of leptin transport across the BBB is caused by a circulating factor. Starvation-induced inhibition of leptin transport across.

Health profile used in workshops to help people make diabetes management decisions. Health profile used in workshops to help people make diabetes management.

MiRNA expression profiling in adipocytes from wild-type (WT) and leptin-deficient ob/ob mice. miRNA expression profiling in adipocytes from wild-type (WT)

BAFF-deficient (BAFFnull) and anti-BAFF antibody (Ab)–treated obese mice exhibit superior glucose metabolic control compared with WT and Bnull mice. BAFF-deficient.

A summary of CCM3-mediated signalling pathways implicated in CCM formation. A summary of CCM3-mediated signalling pathways implicated in CCM formation.

Model for insulin-mediated inhibition of adrenomedullin transcription and its consequences on adipocyte differentiation. Model for insulin-mediated inhibition.

The effect of VSG on body weight and body fat in GLP-1r KO mice.

A: Chemical structure of pterosin A

Reduced OXPHOS expression and increased UCP expression.

VIP treatment decreased the number of apoptotic cells and increased cell proliferation. VIP treatment decreased the number of apoptotic cells and increased.

Effect of PEDF+DHA treatment on wound healing in diabetic corneas.

SENP2 overexpression increases FAO by upregulating expression of FAO-associated enzymes in muscle. SENP2 overexpression increases FAO by upregulating expression.

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

Treatment of high-fat diet–fed mice with TTR-ASOs decreases circulating TTR and RBP4 levels, and improves insulin sensitivity. Treatment of high-fat diet–fed.

PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded skin. PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded.

Summary of STICH trial patients included in the analysis of 6 min walk distance. Reasons for non-inclusion at each follow-up time are given. CABG, coronary.

Urinary albumin excretion and histology of glomeruli.

Energy stores in quadriceps muscles at rest (white bars) and after treadmill exercise (black bars) in WT and HSL KO mice. Energy stores in quadriceps muscles.

A suggested model for the role of CPPED1 in glucose metabolism.

Expression of PKCδ in islets and other tissues of control and PKCδKN-overexpressing mice. Expression of PKCδ in islets and other tissues of control and.

GTTs and ITTs. A: GTTs of WT (◇), LepTg (♦), Akita (open circles), and LepTg:Akita (closed circles) mice at 8 and 16 weeks of age. GTTs and ITTs. A: GTTs.

Summary of the new mechanistic findings of the present study.

In situ hybridization. In situ hybridization. The expression pattern of VEGF-R2, angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2), the angiopoietin receptor.

Lipoprotein lipase is decreased in skeletal muscle of young, lean IR offspring of T2D parents. Lipoprotein lipase is decreased in skeletal muscle of young,

DPP-4 enhances M1 polarization and inhibits M2 polarization in macrophages in an ROS-dependent manner. DPP-4 enhances M1 polarization and inhibits M2 polarization.

Result of coronary angiogram among patients with and without diabetes admitted with first-time acute coronary syndrome (a significant stenosis was defined.

Kaplan-Meier estimate of mortality in the two treatment strategies with significant difference between the two groups (log-rank test

Case report: male 63 years old with documented stenosis of the internal cerebral artery, diabetes duration 12 years, and treatment with 22 IU insulin glargine.

Schematic view of intracellular signaling cascades triggered by receptor tyrosine kinase in Schwann cells. Schematic view of intracellular signaling cascades.

Vandetanib decreases tumor incidence and accumulation of HIF-2α, expression of c-Myc and growth factor receptors in the lung of hypoxic mice. Vandetanib.

The critical roles of miR-23a and miR-27a in colorectal cancer progression. miR-23a primarily increases cell motility through downregulation of its target.

ERM proteins promote CD44 cleavage.

The solid line represents the point estimate of the treatment ORs at various levels along the x-axis that ranges from the minimum to the maximum observed.

Curative effect of W+T treatment in vivo.

Transcriptome profiling of PD-L1 antibody–treated macrophages showed inflammatory phenotype, increased survival and proliferation, and decreased apoptosis.

Presentation transcript:

Schematic summary of ROS signaling on coronary artery malformation in the offspring of pregestational diabetic mice. Schematic summary of ROS signaling on coronary artery malformation in the offspring of pregestational diabetic mice. Pregestational diabetes increases ROS through hyperglycemia. ROS production inhibits HIF-1α and Wt1 expression in the fetal heart. Downregulation of Wt1 decreases epicardial EMT and results in coronary artery malformation through inhibition of Snail/Slug and RALDH2/bFGF pathways. All these abnormalities were prevented by treatment with NAC in the diabetic dams. Hoda Moazzen et al. Diabetes 2015;64:1431-1443 ©2015 by American Diabetes Association