Allison J. Burbank, MD, Charity G

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Presentation transcript:

A short course of gamma-tocopherol mitigates LPS-induced inflammatory responses in humans ex vivo Allison J. Burbank, MD, Charity G. Duran, PhD, Martha Almond, RRT, Heather Wells, BS, Sha'Leema Jenkins, BA, Qing Jiang, PhD, Chao Yang, MPhil, Ting Wang, MS, Haibo Zhou, PhD, Michelle L. Hernandez, MD, David B. Peden, MD, MS Journal of Allergy and Clinical Immunology Volume 140, Issue 4, Pages 1179-1181.e4 (October 2017) DOI: 10.1016/j.jaci.2017.04.030 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Plasma γT and γ-CEHC concentrations increased significantly from baseline at the 24- and 30-hour time points; analyses performed using Wilcoxon matched-pairs signed rank test (n = 10). B, PBMCs were isolated from blood samples at baseline and 30 hours and stimulated with LPS for 24 hours. LPS-induced IL-1β and IL-6 were significantly reduced after γT supplementation (data represented as medians and quartiles); analyses performed using paired t testing (n = 10). Journal of Allergy and Clinical Immunology 2017 140, 1179-1181.e4DOI: (10.1016/j.jaci.2017.04.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Change in plasma γ-CEHC concentration was significantly negatively correlated with change in LPS-induced IL-8 production by PBMCs (r = −0.76; P = .01), suggesting that a greater increase in γ-CEHC with γT supplementation results in reduced IL-8 production during LPS challenge. Journal of Allergy and Clinical Immunology 2017 140, 1179-1181.e4DOI: (10.1016/j.jaci.2017.04.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 PBMCs demonstrated reduced gene expression of IL6 following γT supplementation (n = 7). IL1β and PTGS2 expressions were also modestly reduced (n = 7). Analyses were performed using repeated-measures ANOVA and corrected for multiple comparisons by controlling for false-discovery rate. PTGS2, Prostaglandin-endoperoxide synthase 2. Journal of Allergy and Clinical Immunology 2017 140, 1179-1181.e4DOI: (10.1016/j.jaci.2017.04.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions