IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma Michael Kabesch, MD, Michaela Schedel, MSc, David Carr, MSc, Bernd.

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Presentation transcript:

IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma Michael Kabesch, MD, Michaela Schedel, MSc, David Carr, MSc, Bernd Woitsch, MD, Christian Fritzsch, MD, Stephan K. Weiland, MD, Erika von Mutius, MD Journal of Allergy and Clinical Immunology Volume 117, Issue 2, Pages 269-274 (February 2006) DOI: 10.1016/j.jaci.2005.10.024 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Schematic depiction of the IL-4/IL-13 pathway. Activation of receptors containing IL-4Rα by IL-4 or IL-13 led to the phosphorylation (by Janus kinases [JAK]) and transduction of STAT6 into the nucleus, inducing IgE production via target genes. Journal of Allergy and Clinical Immunology 2006 117, 269-274DOI: (10.1016/j.jaci.2005.10.024) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Combinations of alleles in the IL-4/IL-13 pathway increase the risk to develop elevated serum IgE levels (90th percentile). In the upper panel, effects of single SNPs are shown. In the middle panel, haplotype pairs, and in the lower panel, haplotype triplets are presented. ∗Haplotypes from genotype combinations showing statistically significant epistatic interactions. Journal of Allergy and Clinical Immunology 2006 117, 269-274DOI: (10.1016/j.jaci.2005.10.024) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Single SNPs and combinations of SNPs in the IL-4/IL-13 pathway increase the risk of developing asthma. In the upper panel, effects of single SNPs are shown. In the middle panel, haplotype pairs, and in the lower panel, haplotype triplets are presented. ∗Haplotypes from genotype combinations showing statistically significant epistatic interactions. Journal of Allergy and Clinical Immunology 2006 117, 269-274DOI: (10.1016/j.jaci.2005.10.024) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions