Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells.

Slides:

Advertisements

Similar presentations

Insulin and glucagon secretion: nondiabetic and diabetic subjects.

Advertisements

Cytotoxicity of MSP samples to normal and cancer cell lines.

(A) T2DM: serum glucose levels during glucose tolerance test (n=6 per group). (A) T2DM: serum glucose levels during glucose tolerance test (n=6 per group).

Representative images of human islets infected with strains of CVB

Islet mass and β-cell proliferation is decreased in Hhip–/– embryos (Hip1 in figure). Islet mass and β-cell proliferation is decreased in Hhip–/– embryos.

Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet.

Serial measurements of serum glucose, anion gap, serum carbon dioxide, and serum triglycerides throughout the patient's hospital stay. Serial measurements.

A: PPG increment at week 26 for mealtime faster aspart versus IAsp.

Comparison of the protective effects of R and S isomers of LA on insulin-stimulated 2-DG uptake. Comparison of the protective effects of R and S isomers.

Involvement of IRS-1 in L-783,281–stimulated increases in [Ca2+]i and exocytosis. Involvement of IRS-1 in L-783,281–stimulated increases in [Ca2+]i and.

Mean (95% CI) fasting s-glucose at baseline and 6-month, 12-month, and 24-month follow-up, overall and by sex (A), and by baseline age (B), education (C),

Decreased GLP-1 receptor expression in islets after exposure to high glucose. Decreased GLP-1 receptor expression in islets after exposure to high glucose.

1018-NT-β-cell clusters protect mice from STZ-induced diabetes.

Fatty acid incorporation into triglycerides, triglyceride content, glycerol release, and fatty acid efflux in wild-type and +CD36 myotubes. Fatty acid.

Plasma glucose (A) and glucose specific activity (B) during euglycemic clamp experiments. Plasma glucose (A) and glucose specific activity (B) during euglycemic.

TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin resistance. TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin.

Effect of PIs on insulin release by downstream insulin secretogogues.

Cathepsin D in wild-type and Nuc1 RPE

Models of the mechanisms by which sulfonylureas and glucose control glucagon release. Models of the mechanisms by which sulfonylureas and glucose control.

Influence of insulin on AdipoR1 mRNA expression in murine C2C12 myotubes. Influence of insulin on AdipoR1 mRNA expression in murine C2C12 myotubes. Data.

Gene set enrichment analysis reveals MafA regulation of many key β-cell activities. Gene set enrichment analysis reveals MafA regulation of many key β-cell.

Human and mouse islets express MCH and MCHR1.

Insulin promoter confers β-cell–specific GFP expression in pancreas.

Cell proliferations, ROS production, and ATP levels in HASMCs cultured under high-glucose condition. Cell proliferations, ROS production, and ATP levels.

Glycemia and glucose tolerance of RIP-N mice.

Fragment N expression does not affect islet morphology and cellularity

A single dose of liraglutide (Lira) (7. 5 μg/kg or 0

Comparison of women carrying a male fetus and those carrying a female fetus, with respect to mean adjusted blood glucose levels during the OGTT (A), mean.

Measurement of insulin release from islets evoked by glucose, diazoxide, and high K+. Measurement of insulin release from islets evoked by glucose, diazoxide,

The underlying physiological basis of the HOMA model.

Grg3 is expressed in most β-cells but less frequently in α-cells.

Lower SNS activity in WAT of fasted Ugcgf/f//CamKCreERT2 mice.

Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose.

Effect of blockade of the Fas receptor on glucose- and interleukin-1β–induced β-cell DNA fragmentation and proliferative activity. Effect of blockade of.

Npas4 induction is cytoprotective for pancreatic β-cells.

GLP-1 and gastrin combination therapy increases pancreatic insulin content (A) and β-cell mass (B) in NOD mice. GLP-1 and gastrin combination therapy increases.

Involvement of PKCα in downregulation of GLP-1 receptor by high glucose in isolated rat islets. Involvement of PKCα in downregulation of GLP-1 receptor.

Chop deletion preserves β-cell function in P58IPK−/− mice.

Odor-induced brain responses in patients with type 2 diabetes (A) and normal control subjects (B) (with AlphaSim correction, voxel level: P < 0.001, cluster.

Adoptive transfer of purified activated G9Cα−/−

GLP-1 and gastrin combination therapy induces immunoregulatory cell activity in NOD mice. GLP-1 and gastrin combination therapy induces immunoregulatory.

ChREBPα increases β-cell mitochondrial activity and ATP production in human islets. ChREBPα increases β-cell mitochondrial activity and ATP production.

Glucose stimulates GLP-1 secretion from the perfused rat intestine by a dose- and absorption-dependent manner. Glucose stimulates GLP-1 secretion from.

The lack of effect of denatonium to stimulate insulin release in the absence of extracellular Ca2+ or in the presence of 10 μmol/l nitrendipine. The lack.

Npas4 is a stress-induced factor in pancreatic β-cells.

A: Comparison of the glucose-dependent insulinotropic effects of efaroxan and phentolamine. A: Comparison of the glucose-dependent insulinotropic effects.

Insulin resistance and hepatic steatosis in ASKO mice.

Effect of high glucose and agents that alter mitochondrial metabolism on ROS production and expression of COX-2 mRNA in HMCs. Cells were incubated with.

Functional promoter activity of the human COX-2 gene in HMCs

Glucose-stimulated insulin secretion, plasma glucagon levels, and pancreatic hormone contents. Glucose-stimulated insulin secretion, plasma glucagon levels,

Western blot of MDA-modified proteins in FVB control, OVE26 diabetic, and catalase-protected OVE26C diabetic hearts. Western blot of MDA-modified proteins.

Assay of ROS accumulation in cells exposed to high levels of glucose.

Intracellular electrical recordings from islet β-cells exhibiting three types of oscillations. Intracellular electrical recordings from islet β-cells exhibiting.

PKA inhibitors do not markedly affect the potentiation of glucose-induced insulin release by GLP-1. PKA inhibitors do not markedly affect the potentiation.

Loss of Phb2 in β-cells induces development of diabetes over a 3-week period in β-Phb2−/− mice. Loss of Phb2 in β-cells induces development of diabetes.

RT-PCR quantification of ubiquitination gene transcripts in rat islets exposed to 2.8 or 16.7 mmol/l glucose for 2 h (A) or 24 h (B). RT-PCR quantification.

Increased pancreatic insulin content and islet size and protection against HFD- and palmitate-induced cell death in PKCδKN-overexpressing mice. Increased.

Chronic rapamycin treatment impairs β-cell mass and insulin clearance in rats. Chronic rapamycin treatment impairs β-cell mass and insulin clearance in.

Blood glucose levels in chicken embryos.

ADCY5 targets nonmetabolic processes to alter Ca2+ responses.

Effect of GSK-3 inhibitors on basal and insulin-stimulated glucose uptake in human muscle cells. Effect of GSK-3 inhibitors on basal and insulin-stimulated.

Correlations between leptin DNA methylation and 2-h post-OGTT glucose levels, within the IGT group (A and B), leptin DNA methylation and mRNA levels (C.

Median (interquartile range) of sensor glucose (A) and insulin delivery (B) during closed-loop (solid red line and red shaded area) and control period.

The hyperbolic relationship between fasting insulin and Si (A) and AIRg and Si (B) for NFG (FPG

Distribution of daily frequency of BGM

Peptide dose-response curves were done to estimate the avidity of these HTL for peptide TARP1-14 (A) and TARP14-27 (B-E) using autologous PBMCs and dendritic.

PKCζ is tyrosine phosphorylated by EGF and contributes to EGF-induced activation of ERK in Mef cells. PKCζ is tyrosine phosphorylated by EGF and contributes.

WM volume did not show the expected increase in volume with age in children with type 1 diabetes (●), in contrast with HC subjects (▲) who showed the (expected)

Receiver operator characteristic (ROC) curve for fasting blood glucose (FBG) predicting posttransplantation diabetes (PTD) using time 0 FBG (a) and screening.

Cumulative mean numbers of confirmed (plasma glucose ≤3

Presentation transcript:

Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells. Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells. (A) Total islet Zn+2 content was reduced to 56% in 3-month-old Mafa∆panc islets and 37% in Mafa∆panc;Mafb+/− islets (wild-type, n = 10; Mafa∆panc, n = 9; Mafa∆panc;Mafb+/−, n = 5). *P < 0.05; **P < 0.01. (B) Normalized glucose dose-response curve of NAD(P)H levels in 3-month-old wild-type, Mafa∆panc, and Mafa∆panc;Mafb+/− islets (n = 4). The NAD(P)H response was not significantly different from base line until 20 mmol/L glucose. *P < 0.05, independent samples. arb., arbitrary. Yan Hang et al. Diabetes 2014;63:1994-2005 ©2014 by American Diabetes Association