Endocrine-disrupting chemicals and uterine fibroids

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Endocrine-disrupting chemicals and uterine fibroids Tiffany A. Katz, Ph.D., Qiwei Yang, Ph.D., Lindsey S. Treviño, Ph.D., Cheryl Lyn Walker, Ph.D., Ayman Al-Hendy, M.D., Ph.D. Fertility and Sterility Volume 106, Issue 4, Pages 967-977 (September 2016) DOI: 10.1016/j.fertnstert.2016.08.023 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Developmental exposure to endocrine-disrupting chemicals (EDCs) induces genetic/epigenetic abnormalities in myometrial stem cells, which lead to uterine fibroid (UF) development. Environmental factors including EDCs induce genetic/epigenetic alterations, thereby leading to the conversion of myometrial stem cells into tumor initiating cells, eventually giving rise to the formation of UFs. Fertility and Sterility 2016 106, 967-977DOI: (10.1016/j.fertnstert.2016.08.023) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions