Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants. Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants.

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Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants. Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants. (A-C) Cross-sections of retinas from wild-type (wt), bgm and dbb animals raised in standard 12-h light/dark cycles (L/D), with bgm and dbb mutants showing normal patterns of degeneration. (D-F) Constant dark (‘D’) alleviates degeneration, whereas (G-I) constant light (‘L’) exacerbates degeneration. (J) Blinded quantification of neurodegenerative (ND) phenotypes. Scores were compared using one-way ANOVA with Dunnett's. Data points represent biological replicates and are presented with means±s.e.m. ***P<0.001. Arrowheads point to areas of retinal degeneration. Hannah B. Gordon et al. Dis. Model. Mech. 2018;11:dmm031286 © 2018. Published by The Company of Biologists Ltd