Fig. 6 CCR7 neutralizing antibody inhibited CCR7+cell expansion in the kidney, RDLN, and spleen and attenuated renal inflammation and fibrosis. CCR7 neutralizing.

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Fig. 6 CCR7 neutralizing antibody inhibited CCR7+cell expansion in the kidney, RDLN, and spleen and attenuated renal inflammation and fibrosis. CCR7 neutralizing antibody inhibited CCR7+cell expansion in the kidney, RDLN, and spleen and attenuated renal inflammation and fibrosis. (A) Rat anti-mouse CCR7 monoclonal neutralizing antibody intervention scheme in C57BL/6J UUO mouse model. Intervention control: rat anti-mouse IgG. (B) Representative RDLNs and RDLN weight of UUO mice (day 7 after surgery) following CCR7 antibody (Ab) treatment. Percentage of RDLN CCR7-positive cells after CCR7 antibody treatment determined by flow cytometry. (C) Representative spleens and spleen weight of UUO mice (day 7 after surgery) following CCR7 antibody treatment. The numbers of spleen immune cells were determined by flow cytometry. (D) Percentage of CCR7-positive cells and numbers of immune cells of UUO mice (day 7 after surgery) analyzed by flow cytometry. (E) PAS-stained kidney sections and weights of left (affected) kidneys of UUO mice (day 7 after surgery). (F and G) Intrarenal inflammation and fibrosis-related markers in UUO mice (day 7 after surgery) analyzed by qPCR. (H) Total kidney collagen levels (adjusted for tissue weight) in UUO mice (day 7 after surgery) determined by hydroxyproline assay. (I) Interstitial fibrosis determination by Sirius red staining and fibronectin detection. Area of positive staining was counted in HPF. n = 5 mice per group. Statistics were analyzed using the Mann-Whitney U test. n.s. > 0.05, *P < 0.05, **P < 0.01. Values are mean ± SEM. (J) Schematic summarizing the role of kidney and DLN lymphangiogenesis in inflammation and fibrosis. Guangchang Pei et al. Sci Adv 2019;5:eaaw5075 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).