Vitamin B6 Intake, Alcohol Consumption, and Colorectal Cancer: A Longitudinal Population-Based Cohort of Women  Susanna C. Larsson, Edward Giovannucci, Alicja Wolk  Gastroenterology  Volume 128, Issue 7, Pages 1830-1837 (June 2005) DOI: 10.1053/j.gastro.2005.03.005 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Overview of the role of vitamin B6 in DNA synthesis, DNA methylation, detoxification of carcinogens, and protection against oxidative DNA damage. CH3, methyl group; CBS, cystathionine β-synthase; CpG, cytosine-guanine dinucleotide sequence; γ-Cys, γ-cystathionase; dTMP, deoxythymidylate monophosphate; dUMP, deoxyuridylate monophosphate; MS, methionine synthase; MTHFR, 5,10-methylenetetrahydrofolate reductase; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; SHMT, serine hydroxymethyltransferase; TS, thymidylate synthase; 5,10-methyleneTHF, 5,10-methylenetetrahydrofolate; 5-methylTHF, 5-methyltetrahydrofolate. Gastroenterology 2005 128, 1830-1837DOI: (10.1053/j.gastro.2005.03.005) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Multivariate rate ratio of colorectal cancer as a function of dietary vitamin B6 intake. Data were fitted by a restricted cubic spline Cox proportional hazards model, adjusted for age (in months; continuous), body mass index (quartiles), education (less than high school, high school, or university), total energy intake (continuous), and quartiles of intakes of red meat, saturated fat, calcium, folate, β-carotene, and cereal fiber. The solid line represents point estimates; dashed lines represent 95% confidence intervals. Gastroenterology 2005 128, 1830-1837DOI: (10.1053/j.gastro.2005.03.005) Copyright © 2005 American Gastroenterological Association Terms and Conditions