Illustration of isotype switching associated with disease susceptibility. Illustration of isotype switching associated with disease susceptibility. We.

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Presentation transcript:

Illustration of isotype switching associated with disease susceptibility. Illustration of isotype switching associated with disease susceptibility. We hypothesize that while the predominant GAD65Ab isotypes in the susceptible subject will be of IgG1 and IgG3, the majority of GAD65Abs in nonsusceptible subjects will be of the IgM class and disappear during follow-up. Only a small percentage will switch to IgG. Catherine Pihoker et al. Diabetes 2005;54:S52-S61 ©2005 by American Diabetes Association