Baseline Q Waves and Time From Symptom Onset to ST-segment Elevation Myocardial Infarction: Insights From PLATO on the Influence of Sex Naji Kholaif,

Slides:

Advertisements

Similar presentations

Outcomes of a Pharmacoinvasive Strategy for Successful Versus Failed Fibrinolysis and Primary Percutaneous Intervention in Acute Myocardial Infarction.

Advertisements

Arch Intern Med. 2007;167(1): doi: /archinte Figure Legend:

Electrocardiographic Criteria for Detecting Acute Myocardial Infarction in Patients With Left Bundle Branch Block: A Meta-analysis Jeffrey A. Tabas,

Not Necessarily a Myocardial Infarction: New Left Bundle Branch Block

The Epidemic of the 20th Century: Coronary Heart Disease

Paul D. Stein, MD, Fadi Matta, MD, Mary J. Hughes, DO

Optimal Systolic Blood Pressure Target After SPRINT: Insights from a Network Meta- Analysis of Randomized Trials Sripal Bangalore, MD, MHA, Bora Toklu,

New-onset Atrial Fibrillation Predicts Heart Failure Progression

The Effect of Smoking on the Risk of Sciatica: A Meta-analysis

Personalized Activity Intelligence (PAI) for Prevention of Cardiovascular Disease and Promotion of Physical Activity Bjarne M. Nes, PhD, Christian R.

Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women Xuemei Sui, MD, MPH, PhD, Mark A. Sarzynski,

Laszlo Littmann, MD, PhD The American Journal of Medicine

Discharge Heart Rate and Mortality after Acute Myocardial Infarction

Ahmed Abuzaid, MD, Carly Fabrizio, DO, Kevin Felpel, MD, Haitham S

Duration of Dual Antiplatelet Therapy in Patients with an Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Chirag Bavishi, MD, MPH,

Long-term Trends in Short-term Outcomes in Acute Myocardial Infarction

Masaya Koshizaka, MD, PhD, Renato D. Lopes, MD, PhD, MHS, L

Impact of More Restrictive Blood Transfusion Strategies on Clinical Outcomes: A Meta- analysis and Systematic Review Shelley R. Salpeter, MD, Jacob S.

Recurrent infarction causes the most deaths following myocardial infarction with left ventricular dysfunction Stein Ørn, MD, John G.F. Cleland, MD, Matti.

Prevalence, Predictors, and Outcomes in Treatment-resistant Hypertension in Patients with Coronary Disease Sripal Bangalore, MD, MHA, Rana Fayyad, PhD,

Early Invasive Versus Initial Conservative Strategies for Women with Non–ST-Elevation Acute Coronary Syndromes: A Nationwide Analysis Islam Y. Elgendy,

Digoxin Use and Lower 30-day All-cause Readmission for Medicare Beneficiaries Hospitalized for Heart Failure Ali Ahmed, MD, MPH, Robert C. Bourge, MD,

CHA2DS2-VASc Score Is Directly Associated with the Risk of Pulmonary Embolism in Patients with Atrial Fibrillation Walid Saliba, MD, MPH, Gad Rennert,

Sudden Cardiac Death From the Perspective of Coronary Artery Disease

Wandering Acute Myocardial Infarction

Todd A. Lee, PharmD, PhD, Brian Bartle, MPH, Kevin B. Weiss, MD, MPH

Body Mass Index and Mortality in Acute Myocardial Infarction Patients

Recent Temporal Trends in the Presentation, Management, and Outcome of Women Hospitalized with Acute Coronary Syndromes Avi Sabbag, MD, Shlomi Matetzky,

Epidemiology of Myelodysplastic Syndromes

The Effect of a Statewide Smoking Ordinance on Acute Myocardial Infarction Rates Paul Basel, BS, Becki Bucher Bartelson, PhD, Marie Claire Le Lait, MS,

The Epidemic of the 20th Century: Coronary Heart Disease

Carotid Sinus Massage in Patients with Suspected Acute Myocardial Infarction, Tachycardia, and Left Bundle Branch Block Teddy Weiss, MD, Yair Elitzur,

Robert Goulden, MBBS, MSc, MPhil, MA The American Journal of Medicine

Sabina Hunziker, MD, MPH, Jennifer Stevens, MD, MS, Michael D

Laszlo Littmann, MD, PhD The American Journal of Medicine

Repeated Heart Rate Measurement and Cardiovascular Outcomes in Left Ventricular Systolic Dysfunction Victoria Hamill, PhD, Ian Ford, PhD, Kim Fox, MD,

Age and Gender Differences in Quality of Care and Outcomes for Patients with ST- segment Elevation Myocardial Infarction Sripal Bangalore, MD, MHA, Gregg.

Kay Lee Park, MD, Robert J. Goldberg, PhD, Frederick A

Adherence to Secondary Prevention Medications and Four-year Outcomes in Outpatients with Atherosclerosis Dharam J. Kumbhani, MD, SM, MRCP, Ph. Gabriel.

Myocardial Infarction Associated with Kawasaki Disease in Adult Man: Case Report and Review of Literature Pranas Serpytis, MD, PhD, Zaneta Petrulioniene,

Differences in the Clinical Features and Outcomes in African Americans and Whites with Myocardial Infarction Rajendra H. Mehta, MD, MS, David Marks,

Optimal Systolic Blood Pressure Target After SPRINT: Insights from a Network Meta- Analysis of Randomized Trials Sripal Bangalore, MD, MHA, Bora Toklu,

Chronic Kidney Disease, Basal Insulin Glargine, and Health Outcomes in People with Dysglycemia: The ORIGIN Study Vasilios Papademetriou, MD, DSc, Eric.

Michael A. Weber, MD, George L

The New Lipid Guidelines: What Do Primary Care Clinicians Think?

Risk Stratification in Non-ST-segment Elevation Acute Coronary Syndromes: Troponin Alone Is not Enough Philippe Gabriel Steg, Gordon FitzGerald, Keith.

Personalized Activity Intelligence (PAI) for Prevention of Cardiovascular Disease and Promotion of Physical Activity Bjarne M. Nes, PhD, Christian R.

Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women Xuemei Sui, MD, MPH, PhD, Mark A. Sarzynski,

Interaction of Physical Activity and Body Mass Index on Mortality in Coronary Heart Disease: Data from the Nord-Trøndelag Health Study Trine Moholdt,

When Guidelines Cause Hypertension

Molly E. Waring, PhD, Jane S

Blood Pressure and Outcomes in Very Old Hypertensive Coronary Artery Disease Patients: An INVEST Substudy Scott J. Denardo, MD, Yan Gong, PhD, Wilmer.

The influence of bilateral internal mammary arteries on short- and long-term outcomes: A propensity score matching in accordance with current recommendations

Yader Sandoval, MD, Stephen W. Smith, MD, Sara A

Does Methylphenidate Reduce the Symptoms of Chronic Fatigue Syndrome?

Elevated High-Density Lipoprotein Cholesterol Is Associated with Hyponatremia in Hypertensive Patients Ariel Israel, MD, PhD, Ehud Grossman, MD The.

Shannon M. Dunlay, MD, MS, Quinn R. Pack, MD, Randal J

Ahmed Abuzaid, MD, Carly Fabrizio, DO, Kevin Felpel, MD, Haitham S

One-way Versus Two-way Text Messaging on Improving Medication Adherence: Meta- analysis of Randomized Trials David S. Wald, MD, FRCP, Shahena Butt, MSc,

Jonathan R. Dalzell, MBChB, MRCP, Colette E

Eosinophilic Myocarditis Presenting as ST-segment Elevation Myocardial Infarction Diagnosed with Cardiac Magnetic Resonance Imaging Grant Bailey, MD,

Acute Reperfusion Therapy in ST-Elevation Myocardial Infarction from

Assessment and Management of Acute Coronary Syndromes (ACS): A Canadian Perspective on Current Guideline-Recommended Treatment – Part 2: ST-Segment Elevation.

Laszlo Littmann, MD, PhD, Michael H. Monroe, MD

Tombstone ST Elevations: … Not Necessarily a Harbinger of Doom!

Diabetes, prediabetes, and cardiovascular risk: Shifting the paradigm

Prevalence and Significance of Unrecognized Renal Dysfunction in Patients with Acute Coronary Syndrome Zach Rozenbaum, MD, Avi Leader, MD, Yoram Neuman,

Preoperative Thienopyridine Use and Outcomes after Surgery: A Systematic Review Anita G. Au, MD, Sumit R. Majumdar, MD MPH, Finlay A. McAlister, MD MSc

Secular trends in cardiovascular disease mortality, incidence, and case fatality rates in adults in the United States Ahmet Ergin, MD, PhD, MPH, Paul.

Sex Differences in the Management and 5-Year Outcome of Young Patients (

Presentation transcript:

Baseline Q Waves and Time From Symptom Onset to ST-segment Elevation Myocardial Infarction: Insights From PLATO on the Influence of Sex Naji Kholaif, MD, Yinggan Zheng, MA, MEd, Pushpa Jagasia, MD, Anders Himmelmann, MD, Stefan K. James, MD, PhD, Philippe Gabriel Steg, MD, Robert F. Storey, MD, DM, Cynthia M. Westerhout, PhD, Paul W. Armstrong, MD The American Journal of Medicine Volume 128, Issue 8, Pages 914.e11-914.e19 (August 2015) DOI: 10.1016/j.amjmed.2015.03.005 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Patient cohort. ECG = electrocardiogram; LBBB = left bundle branch block; MI = myocardial infarction; PCI = percutaneous coronary intervention; STEMI = ST-segment elevation myocardial infarction. The American Journal of Medicine 2015 128, 914.e11-914.e19DOI: (10.1016/j.amjmed.2015.03.005) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 2 (A) Time from symptom onset to electrocardiogram (ECG; per hour) in men and women. (B) Baseline Q waves according to time from symptom onset to ECG for men and women. The American Journal of Medicine 2015 128, 914.e11-914.e19DOI: (10.1016/j.amjmed.2015.03.005) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 3 Associations of baseline Q waves and time to PCI on vascular mortality within 1 year in men and women. P(interaction, sex and baseline Q waves) = .509; P(interaction, sex and time to PCI) = .738. A = adjusted; CI = confidence interval; HR = hazard ratio; PCI = percutaneous coronary intervention; pts = patients; U = unadjusted. *Adjusted for age, systolic blood pressure, heart rate, Killip Class, inferior myocardial infarction. The American Journal of Medicine 2015 128, 914.e11-914.e19DOI: (10.1016/j.amjmed.2015.03.005) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 4 Associations of baseline Q waves and sex on vascular mortality within 1 year according to time to PCI as a continuous variable; P(interaction, sex, and baseline Q waves and time to PCI) = .182. For women with time = 8 hours, 95% CI, 0.85-14.8; with time = 9 hours, 95% CI, 0.77-24.2; with time = 10 hours, 95% CI, 0.69-40.0; with time = 11 hours, 95% CI, 0.61-66.8; with time = 12 hours, 95% CI, 0.54 -112.3. CI = confidence interval; HR = hazard ratio; PCI = percutaneous coronary intervention. *Adjusted for age, systolic blood pressure, heart rate, Killip Class, inferior myocardial infarction. The American Journal of Medicine 2015 128, 914.e11-914.e19DOI: (10.1016/j.amjmed.2015.03.005) Copyright © 2015 Elsevier Inc. Terms and Conditions

Supplementary Figure Time from symptom onset to percutaneous coronary intervention (PCI) per hour on patients with time available in the PLATelet inhibition and patient Outcomes trial (PLATO; n = 4341, median 4.7 [3.1-8.3]). The American Journal of Medicine 2015 128, 914.e11-914.e19DOI: (10.1016/j.amjmed.2015.03.005) Copyright © 2015 Elsevier Inc. Terms and Conditions