Conditions within the kidney that are conducive to C activation.

Slides:

Advertisements

Similar presentations

Human renal primary cells The human kidneys are bean-shaped organs that play several essential regulatory roles. Their main function is to regulate the.

Advertisements

Human renal primary cells The human kidneys are bean-shaped organs that play several essential regulatory roles. Their main function is to regulate the.

Figure 2 Cell-mediated disease mechanisms of lupus nephritis

Figure 4 Expression of coagulation protease receptors in renal cells

Volume 82, Issue 2, Pages (July 2012)

Learning Objective: To Know The Function Of The Bowman’s Capsule

Renal manifestations in Fabry disease and therapeutic options

Paraneoplastic glomerulopathies: New insights into an old entity

Volume 75, Issue 9, Pages (May 2009)

Sanjeev Sethi, Carla M. Nester, Richard J.H. Smith

Figure 2 Prevention of antigen–antibody

Volume 62, Issue 6, Pages (December 2002)

Volume 61, Issue 5, Pages (May 2002)

Volume 90, Issue 1, Pages (July 2016)

Modeling the Glomerular Filtration Barrier: Are You Kidney-ing Me?

Glomerular disease related to anti-VEGF therapy

Volume 75, Issue 11, Pages (June 2009)

Figure 1 Glomerular injury in lupus nephritis

Sickle Cell Nephropathy

Patricia L. St. John, Dale R. Abrahamson Kidney International

Complement in Kidney Disease: Core Curriculum 2015

Hans-Joachim Anders, Volker Vielhauer, Detlef Schlöndorff

VEGF signals via a paracrine loop to VEGFR-2 in the glomerulus.

Apical membrane handling of substances, in this example aminoglycosides, by proximal tubular cells. Apical membrane handling of substances, in this example.

Autosomal dominant distal renal tubular acidosis and the AE1 gene

Volume 77, Issue 9, Pages (May 2010)

Volume 62, Issue 1, Pages (July 2002)

AOPPs and the progression of kidney disease

Filtration function in glomerulonephritis

Volume 54, Issue 2, Pages (August 1998)

Volume 67, Issue 2, Pages (February 2005)

Complement in Kidney Disease: Core Curriculum 2015

An update on the pathogenesis and treatment of IgA nephropathy

A personal hypothetical mechanistic interpretation of idiopathic MN

Macrophages and hypoxia in human chronic kidney disease

primary Sjögren syndrome

Volume 72, Issue 2, Pages (July 2007)

Complement and adaptive immunity.

IgG4-related tubulointerstitial nephritis

AJKD Atlas of Renal Pathology: Minimal Change Disease

AJKD Atlas of Renal Pathology: Focal Segmental Glomerulosclerosis

Immunofluorescence on pronase-digested paraffin sections: A valuable salvage technique for renal biopsies S.H. Nasr, S.J. Galgano, G.S. Markowitz, M.B.

Joshua D. Ooi, A. Richard Kitching Kidney International

Simplified diagrammatic representation of a selection of mechanisms of glomerular injury. Simplified diagrammatic representation of a selection of mechanisms.

New drug toxicities in the onco-nephrology world

Volume 82, Issue 9, Pages (November 2012)

Endothelial cell activation

Molecular defects in C regulation associated with C3 glomerulopathy and atypical hemolytic uremic syndrome. Molecular defects in C regulation associated.

Transmission electron microscopy of a representative glomerular capillary enumerating pathologic changes associated with preeclampsia: 1, endothelial cell.

Pathogenesis of minimal change disease: hypotheses.

A: Scanning electron micrograph illustrating the fenestrated glomerular endothelium. A: Scanning electron micrograph illustrating the fenestrated glomerular.

Novel aspects of complement in kidney injury

Understanding the pathogenesis of IgA nephropathy reveals therapeutic targets. Understanding the pathogenesis of IgA nephropathy reveals therapeutic targets.

Basic structure of the glomerulus and the glomerular filtration barrier. Basic structure of the glomerulus and the glomerular filtration barrier. (A) Each.

IgA nephropathy: markers of progression and clues to pathogenesis

These data are derived from 21,374 patients with any form of glomerular disease identified in renal biopsy specimens evaluated by the University of North.

A schematic presentation of secreted, endocytic, and signaling pattern-recognition receptors. A schematic presentation of secreted, endocytic, and signaling.

Cetuximab (C) is an EGF receptor (EGFR) antibody that causes renal magnesium wasting by competing with EGF for its receptor. Cetuximab (C) is an EGF receptor.

Leukocyte recruitment and behavior in the glomerulus.

Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease T.A.O. Jiang,

Novel therapies target the principal components of the immune system that contribute to LN pathogenesis. Novel therapies target the principal components.

Electron micrograph of chronic primary membranous nephropathy showing discontinuous, electron-dense deposits representing aggregates of PLA2R–anti-PLA2R.

Ultrastructural localization of NKCC2 protein in the TAL and macula densa (MD). Ultrastructural localization of NKCC2 protein in the TAL and macula densa.

A glomerulus exhibits mesangiolysis, endothelial denudation, red blood cell congestion, and glomerular basement membrane duplication in this example of.

Absolute renal biopsy diagnosis frequencies of the most common glomerular disease subtypes according to patient age category. Absolute renal biopsy diagnosis.

Collapsing glomerulopathy (CG) and lesions that may resemble CG histologically in renal biopsies from patients with systemic lupus erythematosus. Collapsing.

Tubulointerstitial changes and arteriolar hyalinosis in diabetic kidney disease. Tubulointerstitial changes and arteriolar hyalinosis in diabetic kidney.

A glomerulus exhibits global wrinkling and retraction of the glomerular basement membrane and diffuse swelling and hyperplasia of overlying visceral epithelial.

Relative renal biopsy diagnosis frequencies of the most common glomerular disease subtypes according to patient age category and typical mode of clinical.

Tissue proteomics: a new investigative tool for renal biopsy analysis

Presentation transcript:

Conditions within the kidney that are conducive to C activation. Conditions within the kidney that are conducive to C activation. The C cascade is activated by distinct mechanisms at various ultrastructural locations within the kidney. Immune-complexes can deposit in the mesangium and at different locations within the glomerular capillary wall. In some diseases, autoantibodies bind to specific renal antigens. Other conditions in the kidney that favor C activation are increased concentrations of C proteins in the efferent vessels, low pH, increased local concentrations of C proteins due to production by tubular epithelial cells, and high concentrations of ammonia which can activate the alternative pathway. The glomerular basement membrane does not express C regulatory proteins, although factor H controls alternative pathway activation on the glomerular basement membrane. The apical surface of tubular epithelial cells also does not express C regulatory proteins, and alternative pathway proteins may be activated at this location in proteinuric conditions. EC, endothelial cell; PO, podocyte; fB, factor B; fD, factor D. Joshua M. Thurman, and Carla M. Nester CJASN 2016;11:1856-1866 ©2016 by American Society of Nephrology