Delivering Three Punches to Knockout Intracellular Bacteria

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Delivering Three Punches to Knockout Intracellular Bacteria Emilie Narni-Mancinelli, Eric Vivier Cell Volume 157, Issue 6, Pages 1251-1252 (June 2014) DOI: 10.1016/j.cell.2014.05.023 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 A Two-Step Process for Targeting Intracytoplasmic Bacteria Step 1. Perforin binds to the cell membrane and generates pores allowing the delivery of lytic granule content into the infected cell. Step 2. Granulysin penetrates the bacterial membrane to facilitate the entry of granzymes into intracytoplasmic bacteria. While granzymes can limit bacterial spreading by inducing apoptosis of infected cells, direct delivery of granzymes into bacteria mediated by granulysin eliminates bacteria independently of host cell death. Cell 2014 157, 1251-1252DOI: (10.1016/j.cell.2014.05.023) Copyright © 2014 Elsevier Inc. Terms and Conditions