Hyperthermic intraoperative pleural cisplatin chemotherapy extends interval to recurrence and survival among low-risk patients with malignant pleural.

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Hyperthermic intraoperative pleural cisplatin chemotherapy extends interval to recurrence and survival among low-risk patients with malignant pleural mesothelioma undergoing surgical macroscopic complete resection David J. Sugarbaker, MD, Ritu R. Gill, MD, Beow Y. Yeap, ScD, Andrea S. Wolf, MD, MPH, Marcelo C. DaSilva, MD, Elizabeth H. Baldini, MD, MPH, Raphael Bueno, MD, William G. Richards, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 145, Issue 4, Pages 955-963 (April 2013) DOI: 10.1016/j.jtcvs.2012.12.037 Copyright © 2013 Terms and Conditions

Figure 1 Kaplan-Meier survival functions for hyperthermic intraoperative cisplatin chemotherapy (HIOC) and comparison groups depicting interval to recurrence for (A) all patients, (B) patients who received adjuvant or neoadjuvant chemotherapy but no adjuvant radiotherapy, (C) patients who received adjuvant or neoadjuvant chemotherapy and adjuvant radiotherapy, (D) patients with N1 or N2 lymph node metastasis demonstrated on final pathologic examination, and (E) patients with N0 status determined by final pathologic examination. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 955-963DOI: (10.1016/j.jtcvs.2012.12.037) Copyright © 2013 Terms and Conditions

Figure 2 Kaplan-Meier survival functions for hyperthermic intraoperative cisplatin chemotherapy (HIOC) and comparison groups depicting overall survival for (A) all patients, (B) patients who received adjuvant or neoadjuvant chemotherapy but no adjuvant radiotherapy, (C) patients who received adjuvant or neoadjuvant chemotherapy and adjuvant radiotherapy, (D) patients with N1 or N2 lymph node metastasis demonstrated on final pathologic examination, and (E) patients with N0 status determined by final pathologic examination. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 955-963DOI: (10.1016/j.jtcvs.2012.12.037) Copyright © 2013 Terms and Conditions

Figure 3 Kaplan-Meier survival functions for hyperthermic intraoperative cisplatin chemotherapy (HIOC) and comparison groups depicting (A) interval to recurrence and (B) overall survival for patients found to have biphasic subtype tumors on final pathologic examination. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 955-963DOI: (10.1016/j.jtcvs.2012.12.037) Copyright © 2013 Terms and Conditions